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This volume inspires. It certainly will be much appreciated by cell biologists all over the world. Quarterly Review of Biology, March 2009 This book is the eagerly awaited second edition of the best-selling Mitochondria, a book widely acknowledged as the first modern, truly comprehensive authored work on the important, scientifically fundamental topic of the cellular organelles known as mitochondria. This new edition brings readers completely up to date on the many significant findings that have occurred in the eight years since the book was first published. As in that seminal first edition, the second edition tackles the biochemistry, genetics, and pathology of mitochondria in different organisms. The new edition provides thorough updates of all literature concerning this vital organelle, its functions, ongoing research surrounding it, and its importance vis-a-vis a broad range of issues in cellular and molecular biology. The book includes detailed descriptions of current and developing technologies around mitochondrial research and discovery, and highlights subjects that are growing, such as the use of proteomics. This book is an invaluable resource for all geneticists, biologists, and educators in life sciences. It is also of interest for advanced students in genetics and molecular biology.

Mitochondria to centra energetyczne komorek. To od nich zalezy, czy wolne rodniki pozbawia nas zdrowia, mlodosci i witalnosci. Tymczasem kazdy moze zapewnic sobie zdrowie dzieki odpowiednio dobranym skladnikom odzywczym i antyoksydantom. Autorzy wyjasniaja, jak powinienes tego dokonac oraz przestrzegaja przed szkodliwymi czynnikami takimi jak jedzenie gorszej jakosci, ekstremalny styl zycia, niewlasciwa woda, uzywki, trucizny srodowiskowe, aldehydy, metale ciezkie czy elektrosmog. Dzieki ich poradom zadbasz o jelita, zredukujesz stres oksydacyjny i zabezpieczysz sie przed chorobami takimi jak miazdzyca, dolegliwosci reumatyczne i srodowiskowe, nowotwory czy cukrzyca. Powstrzymasz tez przyspieszony proces starzenia sie. Skorzystaj z gwarancji dlugiego zdrowia.

Mitochondria are critical organelles in the metabolic regulation of almost all eukaryotic organisms. Knowledge of their biochemistry and molecular biology in plants has been fuelled over recent years by the rapid progress made in genome sequencing and the ability to manipulate gene expression. Plant Mitochondria contains chapters written by many of the world’s leading researchers in this area, bringing together and reviewing for the first time many recent advances. Contents include coverage of mitochondrial dynamics, mitochondrial genome instability, expression of the plant mitochondrial genome, import of nuclear-encoded mitochondrial proteins, mitochondrial respiratory complex biogenesis, supramolecular structure of the OXPHOS system, mitochondrial electron transport and oxidative stress, mitochondrial metabolism, cytoplasmic male sterilities and mitochondrial gene mutations, and the mitochondrion in plant programmed cell death. Plant Mitochondria is an extremely important and timely addition to Blackwell Publishing’s Annual Plant Reviews series. David Logan, well known and respected internationally for his work in this area, has brought together a truly valuable volume of great use and interest to plant scientists, cell and molecular biologists, and biochemists. Libraries in all universities and research establishments where biological sciences are studied and taught should have copies of this important book on their shelves.

This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences.

With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling (especially involving calcium) and of oxidative stress. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail. Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson’s, Huntington’s and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.