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This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences. Получить ссылку |
The Five Dysfunctions of a Team. A Leadership Fable
Автор: Патрик Ленсиони
Год издания:
In The Five Dysfunctions of a Team Patrick Lencioni once again offers a leadership fable that is as enthralling and instructive as his first two best-selling books, The Five Temptations of a CEO and The Four Obsessions of an Extraordinary Executive. This time, he turns his keen intellect and storytelling power to the fascinating, complex world of teams. Kathryn Petersen, Decision Tech's CEO, faces the ultimate leadership crisis: Uniting a team in such disarray that it threatens to bring down the entire company. Will she succeed? Will she be fired? Will the company fail? Lencioni's utterly gripping tale serves as a timeless reminder that leadership requires as much courage as it does insight. Throughout the story, Lencioni reveals the five dysfunctions which go to the very heart of why teams even the best ones-often struggle. He outlines a powerful model and actionable steps that can be used to overcome these common hurdles and build a cohesive, effective team. Just as with his other books, Lencioni has written a compelling fable with a powerful yet deceptively simple message for all those who strive to be exceptional team leaders.
The Five Dysfunctions of a Team. An Illustrated Leadership Fable
Автор: Патрик Ленсиони
Год издания:
The blockbuster bestseller now in a manga edition–fully illustrated and fun to read! Beautifully illustrated by Kensuke Okabayashi, this enthralling edition of Patrick Lencioni's massive bestseller gives readers a new format in which to understand the fascinating, complex world of teams. Kathryn Petersen, Decision Tech's CEO, faces the ultimate leadership crisis: Uniting a team in such disarray that it threatens to bring down the entire company. Will she succeed? Will she be fired? Will the company fail? Lencioni's gripping tale serves as a timeless reminder that leadership requires as much courage as it does insight. Throughout the story, Lencioni reveals the five dysfunctions that go to the heart of why teams–even the best ones–often struggle. He outlines a powerful model and actionable steps that can be used to overcome these common hurdles and build a cohesive, effective team. This is a compelling fable with a powerful, yet deceptively simple message for all those who strive to be exceptional leaders. Kensuke Okabayashi (Jersey City, NJ) is a working illustrator, a graduate of the School of Visual Arts, and an instructor at the Educational Alliance Art School in New York City.
Overcoming the Five Dysfunctions of a Team. A Field Guide for Leaders, Managers, and Facilitators
Автор: Патрик Ленсиони
Год издания:
In the years following the publication of Patrick Lencioni’s best-seller The Five Dysfunctions of a Team, fans have been clamoring for more information on how to implement the ideas outlined in the book. In Overcoming the Five Dysfunctions of a Team, Lencioni offers more specific, practical guidance for overcoming the Five Dysfunctions—using tools, exercises, assessments, and real-world examples. He examines questions that all teams must ask themselves: Are we really a team? How are we currently performing? Are we prepared to invest the time and energy required to be a great team? Written concisely and to the point, this guide gives leaders, line managers, and consultants alike the tools they need to get their teams up and running quickly and effectively.
Hormonal Therapy for Male Sexual Dysfunction
Автор: Mario Maggi
Год издания:
Hormonal therapy offers a potentially powerful approach to the treatment of sexual disorders in men. However the interplay of different hormones within different bodily systems is carefully balanced; judicious judgement is required in the therapeutic use of hormones to minimize unwelcome side effects. A better understanding of how hormones work will help the physician to better tailor therapies for improved sexual responses in men. Hormonal Therapy for Male Sexual Dysfunction will provide the rationale for hormonal therapy in male sexual disorders, explaining the language of sexual endocrinology and its application in clinical practice. The aim of this book is to provide a clinical ‘in the office’ or ‘at the bedside’ guide to effective patient care for sexual medicine physicians, urologists, gynecologists and other health-care providers in practice and in training. The tone will be practical, not academic. The working assumption is that readers want to know what (and what not) might or should be done, without over emphasis on the why. That said, it is important to review the crucial basic science necessary for effective diagnosis and management, and to provide reminders in the context of the practical chapters. It will not be heavily referenced, in line with a more practical approach. This allows for smoother reading (and also relieves the burden of comprehensive citing from authors). Key evidence (clinical trials, Cochrane or other meta analyses) should be summarized in ‘Evidence at a Glance’ boxes and key references such as reviews, major papers can be provided in the ‘selected bibliography’ at the end of each chapter. Practical guidance will be provided through: – the use of algorithms and guidelines where they are appropriate – ‘Tips and Tricks’ boxes – hints on improving outcomes perhaps via practical technique, patient questioning etc – ‘Caution’ warning boxes – hints on avoiding problems, perhaps via contraindications – ‘Science Revisited’ – quick reminder of the basic science principles necessary for understanding
Handbook of Laser-Induced Breakdown Spectroscopy
Автор: Cremers David A.
Год издания:
Starting from fundamentals and moving through a thorough discussion of equipment, methods, and techniques, the Handbook of Laser-Induced Breakdown Spectroscopy provides a unique reference source that will be of value for many years to come for this important new analysis method. The authors, with a total of over 60 years of experience in the LIBS method, use a combination of tutorial discussions ranging from basic principles up to more advanced descriptions along with extensive figures and photographs to clearly explain topics addressed in the text. In this second edition, chapters on the use of statistical analysis and advances in detection of weapons of mass destruction have been added. Tables of data related to analysis with LIBS have been updated. The Handbook of Laser-Induced Breakdown Spectroscopy, Second Edition: provides a thorough but understandable discussion of the basic principles of the method based on atomic emission spectroscopy, including recently available data leading to better characterization of the LIBS plasma; presents a discussion of the many advantages of the method along with limitations, to provide the reader a balanced overview of capabilities of the method; describes LIBS instrumentation ranging from basic set-ups to more advanced configurations; presents a comprehensive discussion of the different types of components (laser, spectrometers, detectors) that can be used for LIBS apparatuses along with suggestions for their use, as well as an up-to-date treatment of the newest advances and capabilities of LIBS instruments; presents the analytical capabilities of the method in terms of detection limits, accuracy, and precision of measurements for a variety of different sample types; discusses methods of sampling different media such as gases, liquids, and solids; presents an overview of some real-world applications of the method, with new emphasis on sampling of biologically and physically dangerous materials; provides an up-to-date list of references to LIBS literature along with the latest detection limits and a unique list of element detection limits using a uniform analysis method; provides annotated examples of LIBS spectra which can serve as references for the general reader and will be especially useful for those starting out in the field.
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