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Demonstrates the advantages of catalytic cascade reactions for synthesizing natural products and pharmaceuticals Riding the wave of green chemistry, catalytic cascade reactions have become one of the most active research areas in organic synthesis. During a cascade reaction, just one reaction solvent, one workup procedure, and one purification step are needed, thus significantly increasing synthetic efficiency. Featuring contributions from an international team of pioneers in the field, Catalytic Cascade Reactions demonstrates the versatility and application of these reactions for synthesizing valuable compounds. The book examines both organocatalysis and transition-metal catalysis reactions, bringing readers up to date with the latest discoveries and activities in all major areas of catalytic cascade reaction research. Catalytic Cascade Reactions begins with three chapters dedicated to organocatalytic cascade reactions, exploring amines, Bronsted acids, and the application of organocatalytic cascade reactions in natural product synthesis and drug discovery. Next, the book covers: Gold-catalyzed cascade reactions Cascade reactions catalyzed by ruthenium, iron, iridium, rhodium, and copper Palladium-catalyzed cascade reactions of alkenes, alkynes, and allenes Application of transition-metal catalyzed cascade reactions in natural product synthesis and drug discovery Engineering mono- and multifunctional nanocatalysts for cascade reactions Multiple-catalyst-promoted cascade reactions All chapters are thoroughly referenced, providing quick access to important original research findings and reviews so that readers can explore individual topics in greater depth. Drawing together and analyzing published findings scattered across the literature, this book provides a single source that encapsulates our current understanding of catalytic cascade processes. Moreover, it sets the stage for the development of new catalytic cascade reactions and their applications.

This ready reference presents environmentally friendly and stereoselective methods of modern biocatalysis. The experienced and renowned team of editors have gathered top international authors for this book. They cover such emerging topics as chemoenzymatic methods and multistep enzymatic reactions, while showing how these novel methods and concepts can be used for practical applications. Multidisciplinary topics, including directed evolution, dynamic kinetic resolution, and continuous-flow methodology are also discussed. From the contents: * Directed Evolution of Ligninolytic Oxidoreductases: from Functional Expression to Stabilization and Beyond * New Trends in the In Situ Enzymatic Recycling of NAD(P)(H) Cofactors * Monooxygenase-Catalyzed Redox Cascade Biotransformations * Biocatalytic Redox Cascades Involving w-Transaminases * Multi-Enzyme Systems and Cascade Reactions Involving Cytochrome P450 Monooxygenases * Chemo-Enzymatic Cascade Reactions for the Synthesis of Glycoconjugates * Synergies of Chemistry and Biochemistry for the Production of Beta-Amino Acids * Racemizable Acyl Donors for Enzymatic Dynamic Kinetic Resolution * Stereoselective Hydrolase-Catalyzed Processes in Continuous-Flow Mode * Perspectives on Multienzyme Process Technology * Nitrile Converting Enzymes Involved in Natural and Synthetic Cascade Reactions * Mining Genomes for Nitrilases * Key-Study on the Kinetic Aspects of the In-Situ NHase/AMase Cascade System of M. imperiale Resting Cells for Nitrile Bioconversion * Enzymatic Stereoselective Synthesis of Beta-Amino Acids * New Applications of Transketolase: Cascade Reactions for Assay Development * Aldolases as Catalyst for the Synthesis of Carbohydrates and Analogs * Enzymatic Generation of Sialoconjugate Diversity * Methyltransferases in Biocatalysis * Chemoenzymatic Multistep One-Pot Processes

The blighted aftermath of a global nuclear showdown, Deathlands exacts a blood price. The living pay it; the dead don't care. For one legendary band of warriors, this barbaric new world holds a chance for redemption: the secrets of the past. They roam a disfigured America, searching for pre-dark tech…seeking the path to a future worth living.Utah's Great Salt Lake Desert remains a death pit of scorching heat, cannies and grim odds. Ryan Cawdor and his group survive the trek there, only to be drugged, robbed and left for the slave trade. Escaping their captors leaves them alive but stripped of their prized gear: their weps, J. B. Dix's glasses, Dr. Mildred Wyeth's medical kit and, worse, her secret codex. The companions must rely on each other to challenge their enemy and settle the score.

Sediment Cascades: An Integrated Approach provides a comprehensive overview that addresses the transport of sediment through the landscape. Suitable for academic researchers, industry practitioners, research students and advanced level undergraduates, seeking detailed knowledge and an up-to-date review of the recent research literature. The emphasis is on contemporary sediment system dynamics with relevance both to landscape management and landform development. Sediment Cascades: An Integrated Approach begins with an explanation of the need for an integrated approach to sediment delivery systems and introduces the main themes of sediment production, delivery, storage and transfer. Further chapters then focus on specific environments from mountains, through floodplains, to estuaries and the continental shelf. Focuses on contemporary sediment system dynamics and current research Covers a sequence of environments from steep mountains to the continental shelf Highlights the continuity of the subject by linking each component area with its adjacent elements