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Demonstrates the advantages of catalytic cascade reactions for synthesizing natural products and pharmaceuticals Riding the wave of green chemistry, catalytic cascade reactions have become one of the most active research areas in organic synthesis. During a cascade reaction, just one reaction solvent, one workup procedure, and one purification step are needed, thus significantly increasing synthetic efficiency. Featuring contributions from an international team of pioneers in the field, Catalytic Cascade Reactions demonstrates the versatility and application of these reactions for synthesizing valuable compounds. The book examines both organocatalysis and transition-metal catalysis reactions, bringing readers up to date with the latest discoveries and activities in all major areas of catalytic cascade reaction research. Catalytic Cascade Reactions begins with three chapters dedicated to organocatalytic cascade reactions, exploring amines, Bronsted acids, and the application of organocatalytic cascade reactions in natural product synthesis and drug discovery. Next, the book covers: Gold-catalyzed cascade reactions Cascade reactions catalyzed by ruthenium, iron, iridium, rhodium, and copper Palladium-catalyzed cascade reactions of alkenes, alkynes, and allenes Application of transition-metal catalyzed cascade reactions in natural product synthesis and drug discovery Engineering mono- and multifunctional nanocatalysts for cascade reactions Multiple-catalyst-promoted cascade reactions All chapters are thoroughly referenced, providing quick access to important original research findings and reviews so that readers can explore individual topics in greater depth. Drawing together and analyzing published findings scattered across the literature, this book provides a single source that encapsulates our current understanding of catalytic cascade processes. Moreover, it sets the stage for the development of new catalytic cascade reactions and their applications.

This ready reference presents environmentally friendly and stereoselective methods of modern biocatalysis. The experienced and renowned team of editors have gathered top international authors for this book. They cover such emerging topics as chemoenzymatic methods and multistep enzymatic reactions, while showing how these novel methods and concepts can be used for practical applications. Multidisciplinary topics, including directed evolution, dynamic kinetic resolution, and continuous-flow methodology are also discussed. From the contents: * Directed Evolution of Ligninolytic Oxidoreductases: from Functional Expression to Stabilization and Beyond * New Trends in the In Situ Enzymatic Recycling of NAD(P)(H) Cofactors * Monooxygenase-Catalyzed Redox Cascade Biotransformations * Biocatalytic Redox Cascades Involving w-Transaminases * Multi-Enzyme Systems and Cascade Reactions Involving Cytochrome P450 Monooxygenases * Chemo-Enzymatic Cascade Reactions for the Synthesis of Glycoconjugates * Synergies of Chemistry and Biochemistry for the Production of Beta-Amino Acids * Racemizable Acyl Donors for Enzymatic Dynamic Kinetic Resolution * Stereoselective Hydrolase-Catalyzed Processes in Continuous-Flow Mode * Perspectives on Multienzyme Process Technology * Nitrile Converting Enzymes Involved in Natural and Synthetic Cascade Reactions * Mining Genomes for Nitrilases * Key-Study on the Kinetic Aspects of the In-Situ NHase/AMase Cascade System of M. imperiale Resting Cells for Nitrile Bioconversion * Enzymatic Stereoselective Synthesis of Beta-Amino Acids * New Applications of Transketolase: Cascade Reactions for Assay Development * Aldolases as Catalyst for the Synthesis of Carbohydrates and Analogs * Enzymatic Generation of Sialoconjugate Diversity * Methyltransferases in Biocatalysis * Chemoenzymatic Multistep One-Pot Processes

*If you love The Butlers, meet QUEENIE! Kimberley Chambers’ new novel and prequel to The Butler series is out on the 23rd Jan – pre-order now!*Three Butlers Two weddings One funeralNobody can hurt you like the ones you love…Blood is thicker than water, love is stronger than hate – and that’s the problem. When your brother has betrayed you, there’s no coming back.Vinny and Michael have always protected each other and provided for the family. Together they were formidable but business always stopped at the front door. Now someone has changed the rules – women and children are fair game and one of the Butlers is going to end up six feet under.Little Vinny is battling not to follow in his father’s footsteps. Sweet Sammi-Lou has just vowed ‘til death do us part, but it’s only a matter of time before the truth comes out about the murder he committed.Dark secrets are spiralling out of control and have the power to destroy them all for good. Is this the final nail in the Butler family coffin?

‘Pure, unadulterated romance’ Best Chick Lit.comThe sounds and scents of the Crimean War are strangling Harry Marlow, shutting him off and silently smothering his soul. But he is a soldier and that is his life, and he can see nothing else besides that. So why should he care when a woman watches him? His life is not one to share with a woman, other than for a few moments in his bed.When a woman is already drowning so deeply in sin she is without any fear of judgement – what can it matter if she choses to begin a new affair? It is like escape to choose her own man and Captain Marlow is the perfect candidate for a dalliance. All she has to do is obtain an introduction…

All that glitters… Merciless businessman Ciro D’Angelo knows an opportunity when he sees it – and Lily Scott’s vulnerable sweetness and old-fashioned values are exactly what he needs in a wife. She’s the complete opposite to the red-taloned gold-diggers who relentlessly pursue him. Isn’t gold…But on their wedding night Ciro realises that Lily isn’t quite the pure bride he expected. Does her virtuous facade hide a fortune-hunter as shameless as the rest? It seems their marriage is over before it’s begun – yet once you’re a D’Angelo wife there’s no turning back…