Найти книгу: "Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria"

Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA’s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable “cross-talk” between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.

Полный вариант заголовка: «The distress'd wife : A comedy / By the late Mr. Gay, author of the Beggar's opera».

Учебное пособие содержит основные теоретические сведения о переводе научно-публицистических текстов, оригинальные и адаптированные тексты на английском и русском языках.

France, XVII century. Young Arabella, not knowing that such wealth and luxury, gets an invitation to the ball. Drugged to flatter the monarch, an innocent girl not notice that he is in the Royal bed. But the fee for the title mistress of the king is too high. The girl will have to visit the intoxicating harem of the East, the flight to sit down on the bed of a hated Sultan, to appear before himself with the Sacred court. And this is only the beginning of a difficult road leading to true love.

Almost daily we hear people use the word stress, so it seems that almost everyone knows what this phenomenon represents and how to recognize it, not not how to prevent or mitigate its harmful consequences. Stress is a set of emotional, physical, physiological and behavioral responses that occur when an event is thought to be hazardous or disturbing, and beyond our capacity to cope with. Of course, we should not forget that stress is essentially a very positive part of human nature.

"Pohiline on moista, et meditatsioon on seotud jalgimisega. Sa jalgid, mis su sees toimub, olenemata sellest, mis toimub ­umberringi. Kodus, too juures, hommikul, ohtul… Tanapaeva huperaktiivne moistus ei lase sul paigal istuda. Niisiis, jooksu pealt mediteerimine ongi asja voti: olles aktiivne, on jalgimine algul palju lihtsam. Sellest tulenebki selles raamatus kirjeldatud Osho aktiivse meditatsiooni ja teiste tegusatele inimestele moeldud meditatsioonide vaartus. Paradoksaalselt, kui puuad istuda paigal, markad vaid hullumeelselt poorlevat moistust. Kui oled terve tegusa paeva poorelnud ja jalginud, siis markad, et sul on vaikne kese. Void ka avastada, et osa sellest hullust moistusest tuleb minema saata, enne kui suudad lodvestuda ja olla vaikselt.Raamat „Meditatsioon hoivatud inimestele” Osho nouannetega toob sinuni erinevaid enese avastamise viise, milline olukord ka poleks. Void avastada vahemalt selle, kes sa pole.Selle teaduse juures on imetore see, et igauks on oma laboris teadlane. Uskumusi ei nouta. Ega usu kinnitamist. Lihtsalt on vaja teaduslikku lahenemist, kui voetakse hupotees ja seda enda peal katsetatakse. Kui see ebaonnestub, pole probleemi, su paberikorv on ilmselt juba pooleldi tais. Kui onnestub, oled avastanud kuldvotmekese. Pahupool puudub.Teadlased on marganud, et ka normaalsed vanusega kaasnevad muutused on mediteerijatel vahem valjendunud – meditatsioon on kindlasti odavam kui kortsudevastane kreem!