Найти книгу: "Transition Metal-Catalyzed Couplings in Process Chemistry. Case Studies From the Pharmaceutical Industry"

Transition metal-catalyzed coupling reactions have a rich history that led to the awarding of the 2010 Nobel Prize in Chemistry to Professors Suzuki, Heck, and Negishi for their pioneering contributions to the field. The coming of age of this active area of research is showcased in this book through case studies in which process chemists from the pharmaceutical industry share their personal experiences developing their own transition metal-catalyzed couplings for the large-scale manufacture of active pharmaceutical ingredients. Authors from Pfizer, Merck, Boehringer-Ingelheim, Novartis, Amgen, GSK, AstraZeneca, and other companies describe the evolution of robust coupling processes from inception through early and late development, including commercial routes where applicable. This book covers a wide range of coupling transformations while capturing the lessons learned from each process. Every case study details the optimization of at least one transition metal-catalyzed coupling while elaborating on issues such as design of experiments, scalability and throughput, product purification, process safety, and waste management. The important issue of metal removal and the different technologies available to accomplish this goal are also addressed. Finally, a section covers novel technologies for cross-coupling with high potential for future applications on a large scale, such as microwave and flow chemistry as well as green cross-couplings performed in water. With Forewords by Stephen L. Buchwald, Massachusetts Institute of Technology, Trevor Laird, Editor of Organic Process Research and Development and Neal G. Anderson, Anderson's Process Solutions LLC.

`Соло в стиле хэви-метал` является продолжением курса `Ритм-гитара в стиле хэви-метал`. Те из Вас, кто уже имеет некоторый опыт и способны читать ритм, могут начать прямо с этой книги. Однако, если Вы обнаружите, что ритмические рисунки даются Вам с трудом, то Вам придется вернуться к тому разделу `Ритм-гитары в стиле хэви-метал`, в котором более детально описывается ритмика. Книга подготовлена фирмой `Guitar College` для студентов, изучающих тяжелый стиль.

Это первая книга серии "Гитара в стиле Heavy Metal", в которой с самого начала на практических примерах и упражнениях Вы сможете освоить стиль Hard n` Heavy, являющийся основой для всех последующих направлений тяжелой музыки. В книге намеренно отсутствует традиционная нотная запись. Изложение музыкального материала максимально визуализировано (рисунки, диаграммы, ТАБ`ы), что позволяет неподготовленному студенту быстро войти в курс дела. В результате изучивший книгу гитарист приобретает навык чтения ритмической записи, столь необходимый для изучения следующих изданий. Книга подготовлена фирмой Guitar College для студентов, изучающих тяжелый стиль.

Аудиошкола будет полезна гитаристу любого уровня. Специфические гитарные трюки - это фокус, который в состоянии исполнить любой гитарист независимо от уровня владения инструментом. Другими словами, либо они есть, либо их нет в вашем арсенале. Книга содержит несколько разделов на разные виды техники, каждый из которых заканчивается учебным соло, иллюстрирующим пройденный материал.

In the special edition of the “Metal Supply & Sales” magazine you will find the analysis of current situation in Russian ferrous and non-ferrous metallurgy in the context of global production; in depth flat and long-rolled products, pipe, copper and aluminum industry research. English speaking readers of the special edition will be able to acquire information on Russian metallurgy perspectives, market trends and industry innovations. In the “Metal supply & sales” magazine sector’s leading companies – MMK, NLMK, RMK, TMK, OMK, Chelpipe, Uraltrubprom and Ukraine’s Metinvest, present their articles on new production capacities, products and engineering solutions. In addition the Chinese market forecast is published in this issue of the magazine. It is well known, that Russian metallurgy is export-oriented. More than 50% of all production is being exported and Russia is considered to be among the five largest suppliers of metals on world markets. Therefore, export contracts have always been, are, and in the nearest future will be crucial for the national producers of steel products. «Metal Supply & Sales» magazine sees its mission as a bridge between the producers and consumers of metals. Therefore English edition, which aims to promote the domestic steel industry on the international markets, is being published. According to the statistics, each magazine is being read by 15 person, so 8 thousand copies are being read by 120,000 people. Over 100 thousand industry representatives from all around the world will be able to examine the maps of Russian metallurgical assets, get the perspective on the traditional and new types of products, and to establish mutually beneficial commercial relationships.

According to the statistics, each magazine is being read by 15 person, so 8 thousand copies are being read by 120,000 people. Over 100 thousand industry representatives from all around the world will be able to examine the maps of Russian metallurgical assets, get the perspective on the traditional and new types of products, and to establish mutually beneficial commercial relationships.