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Sue Petrovski has always been capable, thoughtful, and productive. After retiring from a long and successful career in education, she published two books, ran an antiques business, and volunteered in her community. When her mother was diagnosed with Alzheimer's disease and until her death eight years later, Petrovski served as her primary caregiver. She even cared for her husband when he also succumbed to dementia. However, when Petrovski's husband fell ill with sepsis at the age of eighty-two, it threw everything into question. Would he survive? And if so, would she be able to care for him and manage the family home where they had lived for forty-seven years? More importantly, how long would she be able to do so? After making the decision to sell their house and move into a senior living community, Petrovski found herself thrust into the corporate care model of elder services available in the United States. In <i>Shelved: A Memoir of Aging in America,</i> she reflects on the move and the benefits and deficits of American for-profit elder care. Petrovski draws on extensive research that demonstrates the cultural value of our elders and their potential for leading vital, creative lives, especially when given opportunities to do so, offering a cogent, well-informed critique of elder care options in this country. <i>Shelved</i> provides readers with a personal account of what it is like to leave a family home and enter a new world where everyone is old and where decisions like where to sit in the dining room fall to low-level corporate managers. Showcasing the benefits of communal living as well as the frustrations of having decisions about meals, public spaces, and governance driven by the bottom line, Petrovski delivers compelling suggestions for the transformation of an elder care system that more often than not condescends to older adults into one that puts people first-a change that would benefit us all, whether we are forty, sixty, eighty, or beyond. Получить ссылку |
Drug Repositioning. Bringing New Life to Shelved Assets and Existing Drugs
Автор: Barratt Michael J.
Год издания:
The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.