Скачать книгу - Drug Repositioning. Bringing New Life to Shelved Assets and Existing Drugs
The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.


Bringing extensive reading into the classroom Bringing extensive reading into the classroom

Автор: Richard Day

Год издания: 

Extensive reading brings substantial benefits to language learning. Find out about the importance of extensive free reading, how to develop extensive reading materials, choosing the right graded readers for your class, exploiting class readers, developing class libraries, and setting up and running reading circles.


Bringing online video into the classroom Bringing online video into the classroom

Автор: Jamie Keddie

Год издания: 

Explores principles, techniques and practical ideas for teaching English with video.


Unleashing the Power of IT. Bringing People, Business, and Technology Together Unleashing the Power of IT. Bringing People, Business, and Technology Together

Автор: Dan Roberts

Год издания: 

Go from the «IT guy» to trusted business partner If you're in IT, quite a lot is expected of you and your team: be technologically advanced, business-minded, customer-focused, and financially astute, all at once. In the face of unforgiving competition, rampant globalization, and demanding customers, business leaders are discovering that it's absolutely essential to have a strong, active partner keeping a firm hand on the decisions and strategies surrounding information technology. Unleashing the Power of IT provides tangible, hard-hitting, real-world strategies, techniques, and approaches that will immediately transform your IT workforce and culture, presenting the new mindset, skill set, and tool set necessary for IT leaders to thrive in today's challenging environment. Includes new discussion on social media Offers online access to the IT Skill Builder Competency Assessment Tool Features top ten lists of tips and techniques, proven frameworks, and practical guidance to help you launch and sustain your IT culture change and professional development initiatives Profiling several world-class organizations that have implemented the principles in this book, Unleashing the Power of IT reveals the best practices to get you on the path to implementation.


Bringing Strategy Back. How Strategic Shock Absorbers Make Planning Relevant in a World of Constant Change Bringing Strategy Back. How Strategic Shock Absorbers Make Planning Relevant in a World of Constant Change

Автор: Jeffrey Sampler L.

Год издания: 

Reconsider Strategy and Make Planning Relevant In Bringing Strategy Back, strategy expert Jeffrey Sampler cuts through the clutter to reveal exactly why the usual tools of strategy are so sorely out of sync with our needs: windows of opportunity close far faster than they once did, many of these opportunities are smaller than they once were, growth rates are uneven across markets, and today's competition is more asymmetrical than ever. The upshot for managers is that they need to reorient their approach to absorb the shocks and surprises that strike at a moment's notice. Only then can strategic planning reliably play its part. Leaders all around the world at organizations of any size and type will benefit by shedding their obsolete notions about strategy and becoming more resilient. Bringing Strategy Back rises to the challenge and presents a new prescriptive model. It introduces four «strategic shock absorbers» that enable leaders to build resilient organizations that can withstand even the most unexpected global turbulence. Based on the author's in-depth research in the world's most tempestuous markets, the model delivers several must-have qualities that interact and work together in an ongoing process: Accuracy, Agility, Momentum, and Foresight. With this new framework, Bringing Strategy Back shows how to be prepared and proactive, rather than reactive, even when the future is uncertain.


Corporate Valuation for Portfolio Investment. Analyzing Assets, Earnings, Cash Flow, Stock Price, Governance, and Special Situations Corporate Valuation for Portfolio Investment. Analyzing Assets, Earnings, Cash Flow, Stock Price, Governance, and Special Situations

Автор: Robert Monks A.G.

Год издания: 

A detailed guide to the discipline of corporate valuation Designed for the professional investor who is building an investment portfolio that includes equity, Corporate Valuation for Portfolio Investment takes you through a range of approaches, including those primarily based on assets, earnings, cash flow, and securities prices, as well as hybrid techniques. Along the way, it discusses the importance of qualitative measures such as governance, which go well beyond generally accepted accounting principles and international financial reporting standards, and addresses a variety of special situations in the life cycle of businesses, including initial public offerings and bankruptcies. Engaging and informative, Corporate Valuation for Portfolio Investment also contains formulas, checklists, and models that the authors, or other experts, have found useful in making equity investments. Presents more than a dozen hybrid approaches to valuation, explaining their relevance to different types of investors Charts stock market trends, both verbally and visually, enabling investors to think like traders when needed Offers valuation guidance based on less quantitative factors, namely management quality and factors relating to the company and the economy Corporate Valuation for Portfolio Investment puts this dynamic discipline in perspective and presents proven ways to determine the value of corporate equity securities for the purpose of portfolio investment.