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A revolutionary program that can indefinitely postpone the need for dialysis If you've been diagnosed with kidney failure, this book could save your life. If you suffer from diabetes, hypertension, obesity, or any of a host of conditions that put you at risk for kidney disease, you owe it to yourself to read what is in this book. If you are among the 60,000 North Americans who go on dialysis each year, the information in this book could substantially improve your quality of life. In Coping with Kidney Disease, a leading expert tells you, in plain English, what you need to know to: * Understand kidney failure * Recognize early warning signs of kidney failure * Get a proper diagnosis * Talk with your doctors about it * Confidently evaluate treatment options * Take charge of your treatment * Delay dialysis or even avoid the need for it altogether The centerpiece of Coping with Kidney Disease is Dr. Walser's revolutionary 12-step program for avoiding dialysis. Based on treatments he has pioneered with his own patients at the Johns Hopkins University School of Medicine, the program calls for a supplemented low-protein diet supported by treatments to control blood pressure and correct high cholesterol. So effective has this breakthrough strategy proven to be that in many patients it actually worked to slow or arrest the progression of kidney failure to the end stage. Knowledge is power. Coping with Kidney Disease empowers you with what you need to take charge of kidney disease.

The first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks. Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover: The pathophysiology of COX inhibition on bone, tendon, and ligament healing COX inhibitors and renal system pathophysiology and mechanisms of toxicity The pathophysiologic role of COX inhibition in the ocular system COX inhibition and the respiratory and cardiovascular systems The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs.

Diabetes, when untreated, leads to damage to several organs within the body, particularly the kidneys. This damage may also go undetected for several years, until the later stages of kidney failure are reached, with a need for kidney replacement therapy – either dialysis or transplantation. Such progression is not inevitable. With good management, diabetes can be well controlled and kidney function can be maintained; to a certain extent, the damage can even be reversed. Diabetes and the Kidney is written for people with diabetes, their families and carers. It describes the function of the kidneys, the development of nephropathy, the ways to recognize it early and the correct way to manage it. The title emphasizes how people should take responsibility for their own health, with information on diet, giving up smoking and taking exercise. Clearly written description of kidney function, how it goes wrong in diabetic nephropathy and ways to prevent this Guidance on diet, exercise and generally encouraging people to become involved in their own health care Information on treatment of kidney disease and kidney replacement therapy

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.