Скачать книгу - Data Monitoring Committees in Clinical Trials. A Practical Perspective

The authoritative guide for Data Monitoring Committees—fully revised and updated The number of clinical trials sponsored by government agencies and pharmaceutical companies has grown in recent years, prompting an increased need for interim monitoring of data on safety and efficacy. Data Monitoring Committees (DMCs) are an essential component of many clinical trials, safeguarding trial participants and protecting the credibility and validity of the study. Data Monitoring Committees in Clinical Trials: A Practical Perspective, 2nd Edition offers practical advice for those managing and conducting clinical trials and serving on Data Monitoring Committees, providing a practical overview of the establishment, purpose, and responsibilities of these committees. Examination of topics such as the composition and independence of DMCs, statistical, philosophical and ethical considerations, and determining when a DMC is needed, presents readers with a comprehensive foundational knowledge of clinical trial oversight. Providing recent examples to illustrate DMC principles, this fully-updated guide reflects current developments and practices in clinical trial oversight and offers expanded coverage of emerging issues and challenges in the field. This new second edition covers the most current information on DMC policies, issues in monitoring trials using new designs, and recent trial publications relevant to DMC decision-making. • Presents practical advice for those managing and conducting clinical trials and serving on Data Monitoring Committees • Illustrates the types of challenging issues Data Monitoring Committees face in practical situations • Provides updated and expanded coverage of topics including regulatory and funding agency guidelines and trial designs and their associated demands and limitations • Includes a new chapter addressing legal issues that affect DMC members and discusses general litigation concerns relevant to clinical research • Expands treatment of current journal publications addressing DMC issues Data Monitoring Committees in Clinical Trials: A Practical Perspective, 2nd Edition is a must-have text for anyone engaged in DMC activities as well as trial sponsors, clinical trial researchers, regulatory and bioethics professionals, and those associated with clinical trials in academic, government and industry settings.

Secure PHP Development: Building 50 Practical Applications

Автор: Mohammed J. Kabir

Год издания:

The personal home page (PHP) server-side scripting language is particular well adapted to connecting HTML-based web pages to a backend database for dynamic content. This book explains the entire nuts-and-bolts process of the PHP application life cycle: requirements, design, development, maintenance and tuning. It shows how PHP can be used to design and develop highly manageable and secure applications to solve practical problems.

Практическая грамматика английского языка. Упражнения и комментарии / Practical English Crammar. Exercises and Comments. Учебное пособие

Автор: В. В. Гуревич

Год издания:

Пособие охватывает все разделы английской грамматики, с относительно элементарного уровня до продвинутого. Материал представлен в виде активных заданий, имеющих речевую направленность, и включает упражнения, отрывки связанных текстов (в основном юмористического характера). Для студентов высших учебных заведений, учащихся старших классов школ, а также для всех изучающих английский язык.

Practical aspects of neue kombinationen. Essence of entrepreneurship and settlement relations

Автор: Николай Камзин

Год издания:

The question about the source of additional income has always been central in identifying the essence of entrepreneurship. For the study of any dynamical and structural extensive system requires a lot of intellectual effort. Having learned the essence, identifying potential internal and external display can clearly represent the structure and dynamics of the phenomena deduced. Specifying the study by examining the individual elements, and identifying cause-effect relationship of the dynamic state of the phenomenon and the world around him. International entrepreneurship as a phenomenon involved in the activity in many areas of society. The knowledge of his nature will allow all stakeholders to harmonize the internal mental processes and environmental reality. The consumer uses to access the world's goods. The entrepreneur is critical and represents their innovative ideas. Businessman realizes in practice commercial projects. The State creates conditions for personal development and political and economic means affect the cross-border commodity and cash flows, international payments.

Theory and practical aspects of Internationa settlements. Economic cooperation

Автор: Николай Камзин

Год издания:

As part of the dynamics of international economic cooperation by the need for mutual settlement operations, so the problem of organization of settlements is an important place for the economically active subjects, especially in a globalized economic space in the functioning of transnational structures and scale of the export, import and international financial transactions. In agreeing on the order of calculations, the participants determined the form of payment in order to fulfill the financial obligations of the agreement – regulated by means of voluntary compliance through a credit institution liabilities, characterized by specific features on the order of transfer of funds to the account, a certain kind of settlement document, as well as office procedures. The source of payment relations is the need to have one contractor expressed in the appropriate disposition, the other in shortage. This relationship gives rise as a consequence of the relationship with the lending institution. Need to accession will intensify in the subjects of international payment relationship.

Practical Grammar Exercises of English for Students. Практическая грамматика английского языка для студентов. Сборник упражнений

Автор: А. С. Комаров

Год издания: