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Downstream: Reflections on Brook Trout, Fly Fishing, and the Waters of Appalachia is a mosaic combining nature writing, fly-fishing narrative, memoir, and philosophical and spiritual inquiry. Fly-fishing narratives and fragments of memoir provide the narrative arc for exploring relationships between humans and rivers, and the ways in which our attitudes and philosophies impact our practices and the waters we depend on for life. The authors guide their readers on a journey from Maine's Androscoggin watershed–once one of the ten filthiest rivers in the United States and now home to some of the best wild brook trout fishing in the United States–southward through Kentucky into Tennessee and North Carolina, where a native southern strain of brook trout struggles to survive. Like the rivers themselves, the chapters alternate between flowing narratives and the stiller waters that settle out above dams. While each stone in this mosaic is worth a close look in its own right, seen from a distance the book offers a broader picture of the cold mountain waters of Appalachia and their famous native fish: the brook trout.

An affordable, easily accessible desk reference on biomanufacturing, focused on downstream recovery and purification Advances in the fundamental knowledge surrounding biotechnology, novel materials, and advanced engineering approaches continue to be translated into bioprocesses that bring new products to market at a significantly faster pace than most other industries. Industrial scale biotechnology and new manufacturing methods are revolutionizing medicine, environmental monitoring and remediation, consumer products, food production, agriculture, and forestry, and continue to be a major area of research. The downstream stage in industrial biotechnology refers to recovery, isolation, and purification of the microbial products from cell debris, processing medium and contaminating biomolecules from the upstream process into a finished product such as biopharmaceuticals and vaccines. Downstream process design has the greatest impact on overall biomanufacturing cost because not only does the biochemistry of different products ( e.g., peptides, proteins, hormones, antibiotics, and complex antigens) dictate different methods for the isolation and purification of these products, but contaminating byproducts can also reduce overall process yield, and may have serious consequences on clinical safety and efficacy. Therefore downstream separation scientists and engineers are continually seeking to eliminate, or combine, unit operations to minimize the number of process steps in order to maximize product recovery at a specified concentration and purity. Based on Wiley's Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, this volume features fifty articles that provide information on down- stream recovery of cells and protein capture; process development and facility design; equipment; PAT in downstream processes; downstream cGMP operations; and regulatory compliance. It covers: Cell wall disruption and lysis Cell recovery by centrifugation and filtration Large-scale protein chromatography Scale down of biopharmaceutical purification operations Lipopolysaccharide removal Porous media in biotechnology Equipment used in industrial protein purification Affinity chromatography Antibody purification, monoclonal and polyclonal Protein aggregation, precipitation and crystallization Freeze-drying of biopharmaceuticals Biopharmaceutical facility design and validation Pharmaceutical bioburden testing Regulatory requirements Ideal for graduate and advanced undergraduate courses on biomanufacturing, biochemical engineering, biophar- maceutical facility design, biochemistry, industrial microbiology, gene expression technology, and cell culture technology, Downstream Industrial Biotechnology is also a highly recommended resource for industry professionals and libraries.

A comprehensive review of the current status and challenges for natural gas and shale gas production, treatment and monetization technologies Natural Gas Processing from Midstream to Downstream presents an international perspective on the production and monetization of shale gas and natural gas. The authors review techno-economic assessments of the midstream and downstream natural gas processing technologies. Comprehensive in scope, the text offers insight into the current status and the challenges facing the advancement of the midstream natural gas treatments. Treatments covered include gas sweeting processes, sulfur recovery units, gas dehydration and natural gas pipeline transportation. The authors highlight the downstream processes including physical treatment and chemical conversion of both direct and indirect conversion. The book also contains an important overview of natural gas monetization processes and the potential for shale gas to play a role in the future of the energy market, specifically for the production of ultra-clean fuels and value-added chemicals. This vital resource: Provides fundamental chemical engineering aspects of natural gas technologies Covers topics related to upstream, midstream and downstream natural gas treatment and processing Contains well-integrated coverage of several technologies and processes for treatment and production of natural gas Highlights the economic factors and risks facing the monetization technologies Discusses supply chain, environmental and safety issues associated with the emerging shale gas industry Identifies future trends in educational and research opportunities, directions and emerging opportunities in natural gas monetization Includes contributions from leading researchers in academia and industry Written for Industrial scientists, academic researchers and government agencies working on developing and sustaining state-of-the-art technologies in gas and fuels production and processing, Natural Gas Processing from Midstream to Downstream provides a broad overview of the current status and challenges for natural gas production, treatment and monetization technologies.