Найти книгу: "Epigenetics"

Epigenetics pertains to the development of an organism from an undifferential cell, resulting in the successive formation and development of organs and parts that did not pre-exist in the fertilized egg. An exciting and stimulating volume which used the extensive knowledge of basic transcriptional control as a foundation to explore the more complex and interesting level at which genes can be regulated.

Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical. Toxicology and Epigenetics reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research. Topics covered include: environment, epigenetics and diseases DNA methylation and toxicogenomics chromatin at the intersection of disease and therapy epigenomic actions of environmental arsenicals environment, epigenetics and cardiovascular health toxicology, epigenetics and autoimmunity ocular epigenomics: potential sites of environmental impact in development and disease nuclear RNA silencing and related phenomena in animals epigenomics – impact for drug safety sciences methods of global epigenomic profiling transcriptomics: applications in epigenetic toxicology Toxicology and Epigenetics is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.

Livestock Epigenetics reviews advances in the understanding of the molecular basis of epigenetic mechanisms in gene expression in livestock species. Epigenetics impact many economically important traits from growth and development to more efficient reproduction and breeding strategies. The book opens with a broad introductory chapter that discusses the importance of an understanding of epigenetics to efficient and sustainable livestock production. In subsequent chapters the role of epigenetics in specific aspects of animal production are reviewed. The final chapter provides researchers with a valuable basis for the use of comparative epigenetics research to allow research to apply advances across organisms. Livestock Epigenetics provides detailed information on this rapidly expanding field of research with contributions from a global team of experts.

The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.

The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases. Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field. Specific coverage includes: How highly developed epigenetic mechanisms are involved in several aspects of normal immune regulation, in addition to maintaining immune tolerance to self-determinants. Specific epigenetic aspects of human autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, autoimmune diabetes, thyroid autoimmunity, inflammatory bowel disease and autoimmune hepatitis. How understanding epigenetic mechanisms can lead to therapeutic strategies based on manipulation of this previously unexploited facet of immune regulation. Discussion of the novel approaches that are being investigated to prevent or treat autoimmune diseases. This book is an essential resource for those actively involved in the field. It is also of interest to basic researchers interested in understanding the origin of autoimmunity and clinical specialists interested in gaining in-depth understanding of the pathogenesis of autoimmune diseases and their treatment.

With the discovery of RNAi pathways and the histone code, epigenetics has become a popular and fast evolving research topic. Plant science has made a number of elementary contributions to this field, and the common elements of epigenetic systems have linked research groups interested in plant, fungal and animal systems. This volume provides a comprehensive overview epigenetic mechanisms and biological processes in plants, illustrating the wider relevance of this research to work in other plant science areas and on non-plant systems. It discusses recent advances in our knowledge of basic mechanisms and molecular components that control transcriptional and post-transcriptional silencing, an understanding of which is essential for plant researchers who use transgenic lines for stable expression of a recombinant construct or for targeted inactivation of an endogenous gene. These aspects should be of special interest to the agricultural industry. The volume illustrates the relevance of epigenetic control systems to gene regulation and plant development, examining paramutation, genomic imprinting and microRNA-based gene regulation mechanisms. Finally, it demonstrates the significance of epigenetic systems to viral defence and genome organisation. The volume is directed at researchers and professionals in plant molecular genetics, plant biochemistry and plant developmental biology.