Найти книгу: "Chromosomes"

Integrating classical knowledge of chromosome organisation with recent molecular and functional findings, this book presents an up-to-date view of chromosome organisation and function for advanced undergraduate students studying genetics. The organisation and behaviour of chromosomes is central to genetics and the equal segregation of genes and chromosomes into daughter cells at cell division is vital. This text aims to provide a clear and straightforward explanation of these complex processes. Following a brief historical introduction, the text covers the topics of cell cycle dynamics and DNA replication; mitosis and meiosis; the organisation of DNA into chromatin; the arrangement of chromosomes in interphase; euchromatin and heterochromatin; nucleolus organisers; centromeres and telomeres; lampbrush and polytene chromosomes; chromosomes and evolution; chromosomes and disease, and artificial chromosomes. Topics are illustrated with examples from a wide variety of organisms, including fungi, plants, invertebrates and vertebrates. This book will be valuable resource for plant, animal and human geneticists and cell biologists. Originally a zoologist, Adrian Sumner has spent over 25 years studying human and other mammalian chromosomes with the Medical Research Council (UK). One of the pioneers of chromosome banding, he has used electron microscopy and immunofluorescence to study chromosome organisation and function, and latterly has studied factors involved in chromosome separation at mitosis. Adrian is an Associate Editor of the journal Chromosome Research, acts as a consultant biologist and is also Chair of the Committee of the International Chromosome Conferences. The most up-to-date overview of chromosomes in all their forms. Introduces cutting-edge topics such as artificial chromosomes and studies of telomere biology. Describes the methods used to study chromosomes. The perfect complement to Turner.

A stunning visual collection of the banded metaphase chromosome karyotypes from some 850 species of mammals, the Atlas of Mammalian Chromosomes represents an unabridged compendium of the state of this genomic art form. Bringing together information currently scattered throughout the cytogenetics literature for scores of published and unpublished species, this atlas features high-quality karyotype images for nearly every mammal studied to date, making it the most comprehensive assemblage of high-resolution chromosome photographs available–a critically invaluable resource for today's comparative genomics era. For every available species, the Atlas of Mammalian Chromosomes presents the best karyotype produced, the common and Latin name of the species, the published citation, and the contributing authors. Most karyotypes are G-banded, revealing the chromosomal bar codes of homologous segments among related species. Addressing the mandate of the Human Genome Project to annotate the genomes of other organisms as well, the Atlas of Mammalian Chromosomes offers a step forward in our understanding of species formation, of genome organization, and of DNA script for natural selection. It is an invaluable resource for geneticists, mammalogists, and biologists interested in comparative genomics, systematics, and chromosome structure.

В монографии представлены исследования о структурно-функциональной организации хромосом в популяции клеток костного мозга Rattus norvegicus. Открытие преобразований в структуре у двух пар хромосом позволило выявить хромосомное определение дифференцировки лейкоцитарного, эритроидного, мегакариоцитарного рядов крови, и связь этого процесса с возможностями организма, и действующими на него факторов среды. Книга представляет интерес для генетиков, гематологов, физиологов, биологов, фармакологов.