Найти книгу: "Pathological Pain"

This book brings together contributions from key investigators in the area of pathological pain. It covers the molecular basis of receptors and channels involved in nociception, the possible messages that cause neuropathic plasticity, spinal plasticity in neuropathy, plastic changes in opioid systems in neuropathy and opioid tolerance, and plastic changes related to pathological pain.

Examines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it «the holy grail» of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands. With contributions from many of the world's leading experts on TRP channels, Vanilloid Receptor TRPV1 in Drug Discovery covers the important TRPV1 target for drugs to treat painful conditions such as inflammation, arthritis, and cancer pain. The book discusses: Recent advances in biology, chemistry, and pharmacology at both the preclinical and clinical stage of the dynamic area of TRPV1 drug discovery research The potential for drugs targeting TRPV1 in painful conditions such as inflammation, arthritis, and cancer The development of analgesic drugs Other applications for TRPV1, including the treatment of respiratory disease and diabetes Featuring data relevant to the therapeutic potential of TRPV1 and the medicinal chemistry involved in designing TRPV1 antagonists, Vanilloid Receptor TRPV1 in Drug Discovery is a key tool for researchers in the pharmaceutical industry and academia involved in pain, ion channels, and analgesic drug development.

The surface pigmentation of vertebrates is controlled by specialized cells able to synthesize a variety of pigments collectively known as melanins. Recent research has shown that melanins are produced not only in the skin but also in many other sites such as the eye, inner ear, muscles, etc., – where they are engaged in some unanticipated roles. The details of the synthetic pathway, the complexities of its regulation and biological significance that have been unravelled in recent research comprise a fascinating story and are of key importance in understanding the nature of diseases, including malignant melanoma one of the most rapidly spreading cancers.

Pandemics, epidemics and food borne diseases are a major global challenge. Focusing on the food and farming sector, and mobilising social theory as well as empirical enquiry, Pathological Lives investigates current approaches to biosecurity and ask how pathological lives can be successfully ‘regulated’ without making life more dangerous as a result. Uses empirical and social theoretical resources developed in the course of a 40-month research project entitled ‘Biosecurity borderlands’ Focuses on the food and farming sector, where the generation and subsequent transmission of disease has the ability to reach pandemic proportions Demonstrates the importance of a geographical and spatial analysis, drawing together social, material and biological approaches, as well as national and international examples The book makes three main conceptual contributions, reconceptualising disease as situated matters, the spatial or topological analysis of situations and a reformulation of biopolitics Uniquely brings together conceptual development with empirically and politically informed work on infectious and zoonotic disease, to produce a timely and important contribution to both social science and to policy debate

The past five years have witnessed dramatic advances in research on pathological gambling – a diagnosis often overlooked by clinicians who are unaware not only of the personal and social consequences of pathological gambling, but also of the possible treatment options. Today, clinicians can choose from an array of treatment options to substantially improve the lives of patients with this disabling illness.Eloquently attesting to this extraordinary progress, this remarkable clinician's guide comprises the most extensive coverage on public health, clinical characteristics and treatment, psychotherapy and psychopharmacology, and interventions for adolescents, adults, and older adults. Written by the world's leading researchers on psychiatric aspects of gambling, this truly comprehensive volume discusses how to diagnose pathological gambling and provides the tools to do so. Here, 32 experts detail the clinical phenomenology, etiology, and treatment of pathological gambling, highlighting the current clinical approaches most likely to lead to early identification, symptom remission, and improvement maintenance.Useful appendixes provide specific tests, scales, and diagnostic criteria following four major sections of the book: Public Health and Epidemiology discusses prevalence and definitions of recreational, problem, and pathological gambling; the relationship between the different levels of gambling severity; and gambling's effects on societal, familial, and individual health and well-being. Clinical Characteristics covers the symptoms and sequelae of pathological gambling and the differences among adolescents, older adults, and men and women, and shows that pathological gambling – rather than being categorized as a single disorder – shares important features with many disorders, among them obsessive-compulsive spectrum disorders, affective spectrum disorders, addiction, and impulse-control disorder. Etiology details the realms of both psychology (behavioral, cognitive, and dispositional theories) and neurobiology (noradrenergic, serotonergic, dopaminergic, and opioidergic systems as well as familial and inherited factors) to explain the behavior of pathological gambling – knowledge that may prove useful in understanding a range of addictive and impulsive disorders. Prevention and Treatment emphasizes the vital role of the clinician in prevention efforts, including a prevention strategy tailored specifically for adolescents and young adults; discusses a variety of behavioral and pharmacological interventions for patients including self-help and professional-based interventions for family members; and concludes with assessments useful in diagnosing pathological gambling and monitoring symptom change. Psychiatrists, psychiatric researchers, and other mental health care professionals will welcome this book as their most up-to-date source for invaluable knowledge about and research from the world's recognized experts on pathological gambling.

This straightforward guide offers a complete overview of Pathological Demand Avoidance Syndrome (PDA) and gives practical advice for overcoming the difficulties it poses in a wide range of contexts from diagnosis through to adulthood. Starting with an exploration into the background of PDA that answers many of the immediate questions triggered when a child is first diagnosed, the book goes on to look at the impact of the condition on different areas of the child's life and what can be done to help. The authors present useful information on early intervention options and workable strategies for managing PDA positively on a day-to-day basis. They also examine ways to minimize common difficulties that may be encountered at home and school, making life easier for the child, family and peers. The final chapters tackle new problems that can arise when the teenage years hit and how to assist a successful transition from adolescence to adulthood. Illustrative case examples are included throughout, and the book concludes with a list of valuable resources for further information and advice. Full of helpful guidance and support, this user-friendly introductory handbook is essential reading for anyone caring for, or working with, children with PDA.