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This book serves as a supplement to The Pyrazines, Volume 41 of the Chemistry of Heterocyclic Compounds series. It covers the literature published between 1979 and 2000, and–together with Volume 41–provides a complete, up-to-date reference for heterocyclic chemists. It emphasizes practical approaches to pyrazine chemistry, offers a full appendix of all simple pyrazines up to 2000, and features detailed coverage of the following topics: Systematic descriptions of all primary synthetic routes to pyrazines Other preparative routes to alkylpyrazines and their reactions Halogenopyrazines and their synthetic uses Oxypyrazines and trivial names for pharmaceutical or agrochemical pyrazines Thiopyrazines Amino-, nitro-, and other similar pyrazines and their reactions Pyrazinecarboxylic acids and their derivatives The supplement features extensive cross-references to the original volume and uses chemical nomenclature as per current IUPAC recommendations

Provides an account of the preparation, properties, and uses of the more important bi- and tri-cyclic ring systems incorporating the pyrazine ring. The first 18 chapters survey the developments in the chemistry of quinoxalines since the appearance in 1953 of a previous monograph in this series. The subsequent 22 chapters provide the first authoritative reviews of the chemistry of such important related ring systems as the pyrrolopyrazines.

Complete coverage of chemical literature on simple pyrazines recorded in Beilstein to 1929, and Chemical Abstracts through 1978 (volume 89), together with selected references to 1980. Describes their history, occurrence, biological activity and uses, and nomenclature. Classified primary syntheses of pyrazines according to the starting materials employed. Treats primary syntheses of pyrazine N-oxides. Details syntheses, properties and reactions of alkyl, halogeno, hydroxy, mercapto, amino and carboxy pyrazines and their derivative and related compounds. Extensive table lists known simple pyrazines, physical data such as melting points and boiling points, and references.