Найти книгу: "Osteoarthritic Joint Pain"

Osteoarthritis is a chronic degenerative disease associated with joint pain and loss of joint function. It has an estimated incidence of 4 out of every 100 people and significantly reduces the quality of life in affected individuals. The major symptoms are chronic pain, swelling and stiffness; severe, chronic joint pain is often the central factor that causes patients to seek medical attention. Within the affected joint, there is focal degradation and remodelling of articular cartilage, new bone formation (osteophytes) and mild synovitis. Several mechanisms are thought to contribute to osteoarthritic joint pain. These include mild synovial inflammation, bone oedema, ligament stretching, osteophyte formation and cartilage-derived mediators. Changes in joint biomechanics and muscle strength also influence the severity and duration of joint pain in osteoarthritis. Within the nervous system, the relative contributions of peripheral afferent nociceptive fibres and central mechanisms remain to be defined, and there is limited information on the phenotype of sensory neurons in the OA joint. Importantly, there is no relation between clinical severity, as measured by radiographic changes, and the presence and severity of joint pain. Patients with severe joint pain may have normal joint architecture as determined by X-ray, whereas patients with considerable evidence of joint remodelling may not have significant joint pain. Treatments for osteoarthritic joint pain include non-steroidal anti-inflammatory compounds, exercise, corrective shoes and surgical intervention. There remains a critical need for improved control of joint pain in osteoarthritis. This book brings together contributions from key investigators in the area of osteoarthritic joint pain. It covers the clinical presentation of joint pain, the pathways involved in joint pain, osteoarthritis disease processes and pain, experimental models and pain control. The discussions provide insights into the nature of osteoarthritic joint pain, identify key studies needed to advance understanding of the problem, highlight possible intervention points and indicate future pathways towards a better treatment of osteoarthritic joint pain.

A step-by-step guide to attracting all the investment funds you will ever need for your next real estate transaction As the sales of Real Estate Investing in Canada have proven, Canadians are looking to real estate investing to build wealth. In his bestselling book Real Estate Investing in Canada, Don R. Campbell introduces the Authentic Canadian Real Estate (ACRE) system, the first system of its kind to show ordinary Canadians how to profit from investing in residential real estate. Told as a narrative, a typical Canadian couple named Richard and Emma successfully buy their first properties and now are ready to leverage their equity into more properties. In order to achieve their goals, they are introduced to a joint-venture specialist and, with his guidance, they learn how joint-venture partnerships work and secrets and strategies for acquiring new properties that only the pros know. Richard and Emma build their portfolio – and their confidence – and so they leave their jobs to focus on real estate investing full-time. Following a proven 7-step system, Richard and Emma are equipped with the information, strategies and motivation they need to go to the next level by explaining: What are joint-venture partnerships and how do they work to create win-win relationships Wealth attraction principles-how to become a money magnet How and where to find joint-venture partners-marketing and lead generation–and separate the wheat from the chaff Structuring a joint venture deal-building a team of experts and the due diligence process Legal structures and agreements, including tax implications 19 landmines to avoid in joint venture partnerships Following up with current joint venture partners and duplicating success The appendices offer valuable time-saving checklists, forms and worksheets, as well as advice on paper flow and time management.

Companies of all sizes have been initiating international transactions–mergers and acquisitions, joint ventures, strategic alliances, and private placements–in record numbers. Targeted due diligence is crucial to effectively research, value, and complete these complex deals. With an evolving climate of uncertainty and new, unpredictable threats to business, it is more essential than ever before. Due Diligence for Global Deal Making is an invaluable guidebook for companies trying to capitalize on the opportunities in both developed and emerging cross-border markets. All too often global transactions fail to meet the parties' expectations, and the leading culprit is inadequate due diligence. Especially when the target partner lacks a financial performance track record and significant assets, expanding businesses must answer difficult questions, such as: Why (if at all) do this deal? What are the rules going in, and what happens if things go wrong? Where are the tax, legal, financial, and operational traps, and what are the opportunities? This book provides what’s needed to avoid devastating mistakes and to master the steps that ensure success: Expert analysis, insights, and strategies from experienced practitioners and leading authorities in cross-border matters In-depth coverage of critical topics decision makers need to understand in order to succeed in cross-border transactions–from corporate planning to operational, financial, legal, tax, accounting, and people/organizational considerations Best practices of corporate investors and professional advisers in conducting critical due diligence Noted experts discuss critical topics corporate executives–and all those involved with their company's legal, operational, accounting, and tax matters–need to know to successfully complete complex global transactions today.

Advances in Small Animal Total Joint Replacement provides an up-to-date, comprehensive examination of joint replacement in veterinary surgery. Part of the Advances in Veterinary Surgery series copublished with the ACVS Foundation, the book presents an evidence-based, multi-system examination of the current state of hip, knee, and elbow replacement in dogs and cats, including information on biomechanics and biomaterials not found in other sources. Written by an international group of experts, the book offers guidance on the history, indications, contraindications, clinical procedures, and a review of the current literature for these surgical techniques. Focusing on replacement of the hip, knee, and elbow, the book also covers disc, shoulder, carpus, and tarsus replacement, as well as information on the development of custom prostheses. Each section incorporates information on potential complications and outcomes assessment. Advances in Small Animal Total Joint Replacement is an unparalleled repository of information for veterinary surgeons, residents, and practitioners with an interest in these procedures.

Joining techniques such as welding, brazing, riveting and screwing are used by industry all over the world on a daily basis. A further method of joining has also proven to be highly successful: adhesive bonding. Adhesive bonding technology has an extremely broad range of applications. And it is difficult to imagine a product – in the home, in industry, in transportation, or anywhere else for that matter – that does not use adhesives or sealants in some manner. The book focuses on the methodology used for fabricating and testing adhesive and bonded joint specimens. The text covers a wide range of test methods that are used in the field of adhesives, providing vital information for dealing with the range of adhesive properties that are of interest to the adhesive community. With contributions from many experts in the field, the entire breadth of industrial laboratory examples, utilizing different best practice techniques are discussed. The core concept of the book is to provide essential information vital for producing and characterizing adhesives and adhesively bonded joints.