Найти книгу: "LC/MS Applications in Drug Development"

Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases. In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include: Proteomics Glycoprotein Mapping Natural Products Dereplication Lead Identification Screening Open-Access LC/MS In Vitro Drug Screening Written for both the analytical chemist who uses LC/MS applications and the pharmaceutical scientist who works with the drugs they produce, LC/MS Applications in Drug Development is the premier reference on the subject.

While the success of Open Source software like Linux or Apache has been documented extensively throughout all mainstream media, the rise of PHP has gone largely unnoticed. Still, the Web scripting language PHP is the most popular module for the Apache Web server, according to an E-Soft survey (www.e-softinc.com/survey/). Netcraft studies have found that PHP is in use on over 6% of all Web domains in the world (see www.netcraft.com/survey).That’s an incredible market penetration for a rather specialized product.This popularity continues to rise exponentially. Increasingly, this is being reflected in traditional media: As of May, 2000, more than 20 books about PHP have been published in different languages, with more in the pipeline. Commercial players are beginning to join the bandwagon: PHP is included with Web servers, for example C2’s Stronghold, and Linux distributions. A new company, Zend Technologies, has been formed to provide commercial add-ons and support for PHP.A long list of large-scale Web sites employ PHP, as well as hundreds of thousands of small to medium Web sites.

The personal home page (PHP) server-side scripting language is particular well adapted to connecting HTML-based web pages to a backend database for dynamic content. This book explains the entire nuts-and-bolts process of the PHP application life cycle: requirements, design, development, maintenance and tuning. It shows how PHP can be used to design and develop highly manageable and secure applications to solve practical problems.

Written by members of the Oracle XML group, this is a must-have reference for all IT managers, DBAs, and developers who want to learn the best practices for using XML with Oracle’s XML-enabled products. Includes real-world case studies based on theauthors’ experience managing Oracle’s XML Discussion Forum - a community of 20,000+ XML component users.

Rizzoni is designed for the sophomore/junior level, Introduction to Electrical Engineering course required for non-EE majors. The most widely used book for this course, Rizzoni introduces non-majors to the three basic areas of electrical engineering: circuits, electronics, and electromechanics. The second edition continues the tradition of focusing on the topics and issues of interest to the non-electrical engineering student. To maintain student interest in these topics, Rizzoni provides numerous links between electrical engineering and other engineering fields.