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HPLC for Pharmaceutical Scientists is an excellent book for both novice and experienced pharmaceutical chemists who regularly use HPLC as an analytical tool to solve challenging problems in the pharmaceutical industry. It provides a unified approach to HPLC with an equal and balanced treatment of the theory and practice of HPLC in the pharmaceutical industry. In-depth discussion of retention processes, modern HPLC separation theory, properties of stationary phases and columns are well blended with the practical aspects of fast and effective method development and method validation. Practical and pragmatic approaches and actual examples of effective development of selective and rugged HPLC methods from a physico-chemical point of view are provided. This book elucidates the role of HPLC throughout the entire drug development process from drug candidate inception to marketed drug product and gives detailed specifics of HPLC application in each stage of drug development. The latest advancements and trends in hyphenated and specialized HPLC techniques (LC-MS, LC-NMR, Preparative HPLC, High temperature HPLC, high pressure liquid chromatography) are also discussed.

Every successful organization needs high-performance teams to compete and succeed. Yet, technical people are often resistant to traditional «touchy-feely» teambuilding. To improve communication, performance, and morale among NASA’s technical teams, former NASA Astrophysicist Dr. Charlie Pellerin developed the teambuilding process described in «How NASA Builds Teams»—an approach that is proven, quantitative, and requires only a fraction of the time and resources of traditional training methods. This «4-D» process has boosted team performance in hundreds of NASA project teams, engineering teams, and management teams, including the people responsible for NASA’s most complex systems – the Space Shuttle, space telescopes, robots on Mars, and the mission back to the moon. How NASA Builds Teams explains how the 4-D teambuilding process can be applied in any organization, and includes a fast, free on-line behavioral assessment to help your team and the individual members understand each other and measure the key driver of team performance, the social context. Moreover, these simple, logical processes appeal strongly to technical teams who eschew «touchy-feely» training. Pellerin applies simple, elegant principles from his physics background to the art teambuilding, such as the use of a coordinate system to analyze the characteristics of team performance into actionable elements. The author illustrates the teambuilding process with entertaining stories from his decade as NASA’s Director for Astrophysics and subsequent 15 years of working closely with NASA and outside business teams. For example, he tells how the processes in the book enabled him to initiate the space mission to fix the Hubble Space Telescope’s flawed mirror. Free downloadable resources will help you: Identify your teammates’ innate personalities Diagram your culture (And compare it to your customer’s) Measure the coherency of your project’s paradigm (Get this wrong and you will be fired!) and Learn to meet people’s need to feel valued by you. Further, you can download and use Pellerin’s most powerful tool for influencing the outcome of any difficult situation: the Context Shifting Worksheet.

An in-depth look at big pharma's flagship company The Merck Druggernaut takes readers inside Merck, the world's second most profitable drug company and maker of the world's bestselling drug, Prilosec. Consistently named one of Fortune magazine's Most Admired Companies, Merck struggles to maintain its reputation for being the most ethical of the big drug makers, refusing to slash research and development budgets in the face of declining profits, falling stock market prices, and questionable accounting. Author Fran Hawthorne, one of the leading journalists covering healthcare, has written an excellent examination of a business paragon with much-needed insight on the cutthroat world of pharmaceuticals. It's a story that will interest the business world as well as consumer and healthcare advocates by detailing the vital issues in medicine and healthcare today. More than just a compelling story of success in a difficult industry, more than simply the biography of one of big business's most recognizable names, The Merck Druggernaut takes a thoughtful look at some of the major issues of our time and the way those issues intertwine with the world of business. Fran Hawthorne (New York, NY) is the Assistant Managing Editor at Crain's New York Business. She has been covering business for more than twenty years for such publications as Fortune, BusinessWeek, and Institutional Investor, with a prevailing interest in healthcare and pharmaceuticals. At Crain's, she spearheads the publication of two to three special healthcare issues per year.

Research Ethics for Scientists is about best practices in all the major areas of research management and practice that are common to scientific researchers, especially those in academia. Aimed towards the younger scientist, the book critically examines the key areas that continue to plague even experienced and well-meaning science professionals. For ease of use, the book is arranged in functional themes and units that every scientist recognizes as crucial for sustained success in science; ideas, people, data, publications and funding. These key themes will help to highlight the elements of successful and ethical research as well as challenging the reader to develop their own ideas of how to conduct themselves within their work. Tackles the ethical issues of being a scientist rather than the ethical questions raised by science itself Case studies used for a practical approach Written by an experienced researcher and PhD mentor Accessible, user-friendly advice Indispensible companion for students and young scientists

Maths for Geoscientists is an accessible, student-friendly introduction to the essential mathematics required by those students taking degree courses within the Geosciences. Clearly structured throughout, this book carefully guides the student step by step through the mathematics they will encounter and will provide numerous applied examples throughout to enhance students understanding and to place each technique into context. Opening with a chapter explaining the need for studying mathematics within geosciences the book then moves on to cover algebra, equations, solutions, logarithms and exponentials, statistics and probability, trigonometry, vectors and calculus. The final chapter helps to bring it all together and provides the students with sample projects to test their knowledge. Worked applied examples are included in each chapter along with applied problem questions which are a mix of straightforward maths questions, word questions (developing maths to words), and more involved questions that involve the manipulation and interpretation of real and synthetic data.

The book addresses the basics, applications, and manufacturing of plasmid biopharmaceuticals. The survey of the most relevant characteristics of plasmids provides the basics for designing plasmid products (applications) and processes (manufacturing). Key features that the authors include in the book are: i) consistency and clear line of direction, ii) an extensive use of cross-referencing between the individual chapters, iii) a rational integration of chapters, iv) appellative figures, tables and schemes, and v) an updated, but selected choice of references, with a focus on key papers.