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Functional Metabolism of Cells is the first comprehensive survey of metabolism, offering an in-depth examination of metabolism and regulation of carbohydrates, lipids, and amino acids. It provides a basic background on metabolic regulation and adaptation as well as the chemical logic of metabolism, and covers the interrelationship of metabolism to life processes of the whole organism. The book lays out a structured approach to the metabolic basis of disease, including discussion of the normal pathways of metabolism, altered pathways leading to disease, and use of molecular genetics in diagnosis and treatment of disease. It also takes a unique comparative approach in which human metabolism is a reference for metabolism in microorganisms and plant design, and presents novel coverage of development and aging, and human health and animal adaptation. The final chapter reviews the past and future promise of new genetic approaches to treatment and bioinformatics. This, the most exhaustive treatment of metabolism currently available, is a useful text for advanced undergraduates and graduates in biochemistry, cell/molecular biology, and biomedicine, as well as biochemistry instructors and investigators in related fields.

In a world of fierce global competition and rapid technological change, traditional strategies for gaining market share and achieving efficiencies no longer yield the returns they once did. How can companies drive consumer preference and secure sustainable growth in this digital, social, and mobile age? The answer is through functional integration. Some of the world's most highly valued companies—including Amazon, Apple and Google—have harnessed this new business model to build highly interactive ecosystems of interrelated products and digital services, gaining new levels of customer engagement. Functional integration offers forward-looking brands a unique competitive edge by using transformative digital technologies to deliver high-value customer experiences, generate repeat business, and unlock lucrative new business-to-business revenue streams. Connected By Design is the first book to show business leaders and marketers exactly how to use functional integration to achieve transformative growth within any type of company. Based on R/GA's pioneering work with firms at the forefront of functional integration, Barry Wacksman and Chris Stutzman identify seven principles companies must follow in order to create and deliver new value for customers and capture new revenues. Connected By Design explains how functional integration drove the transformation of market-leading companies as diverse as Nike, General Motors, McCormick & Co., and Activision to establish authentic brand relationships with their customers, enter new categories, and develop new sources of income. With Connected by Design, any company can leverage technological disruption to redefine its mission and foster greater brand loyalty and engagement.

A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. By providing both a solid conceptual understanding of the drug metabolism system, and a well illustrated, detailed demonstration and explanation of cutting edge tools and techniques, this book serves as a valuable reference tool for bench scientists, medical students, and students of general health sciences.

Take advantage of the growing trend in functional programming. C# is the number-one language used by .NET developers and one of the most popular programming languages in the world. It has many built-in functional programming features, but most are complex and little understood. With the shift to functional programming increasing at a rapid pace, you need to know how to leverage your existing skills to take advantage of this trend. Functional Programming in C# leads you along a path that begins with the historic value of functional ideas. Inside, C# MVP and functional programming expert Oliver Sturm explains the details of relevant language features in C# and describes theory and practice of using functional techniques in C#, including currying, partial application, composition, memoization, and monads. Next, he provides practical and versatile examples, which combine approaches to solve problems in several different areas, including complex scenarios like concurrency and high-performance calculation frameworks as well as simpler use cases like Web Services and business logic implementation. Shows how C# developers can leverage their existing skills to take advantage of functional programming Uses very little math theory and instead focuses on providing solutions to real development problems with functional programming methods, unlike traditional functional programming titles Includes examples ranging from simple cases to more complex scenarios Let Functional Programming in C# show you how to get in front of the shift toward functional programming.

Small structural modifications can significantly affect the pharmacokinetic properties of drug candidates. This book, written by a medicinal chemist for medicinal chemists, is a comprehensive guide to the pharmacokinetic impact of functional groups, the pharmacokinetic optimization of drug leads, and an exhaustive collection of pharmacokinetic data, arranged according to the structure of the drug, not its target or indication. The historical origins of most drug classes and general aspects of modern drug discovery and development are also discussed. The index contains all the drug names and synonyms to facilitate the location of any drug or functional group in the book. This compact working guide provides a wealth of information on the ways small structural modifications affect the pharmacokinetic properties of organic compounds, and offers plentiful, fact-based inspiration for the development of new drugs. This book is mainly aimed at medicinal chemists, but may also be of interest to graduate students in chemical or pharmaceutical sciences, preparing themselves for a job in the pharmaceutical industry, and to healthcare professionals in need of pharmacokinetic data.

A multidisciplinary approach that explores the diverse properties, functions, and applications of nanomaterials Drawing together the many scientific and engineering disciplines underlying the development of nanomaterials, Nanoscale Multifunctional Materials provides a multidisciplinary review of the diverse properties, functions, and applications of nanomaterials. The book examines both nanoparticles, which have larger-scale equivalents, and uniquely assembled nanomaterials, which do not have larger-scale equivalents. Readers will gain a tremendous appreciation of the versatility of nanomaterials as well as an understanding of how the same nanomaterial can have several distinct applications across a broad range of fields and industries. Nanoscale Multifunctional Materials is divided into three sections: ? Section I, Overview, describes the scientific phenomena underlying the special properties of nanomaterials, making them desirable as novel materials and different from conventional solids. Next, readers will learn about the effect of nanomaterials on contemporary society as well as future trends in nanomaterials production and use. ? Section II, Processing and Analysis, explores several experimental approaches in nanomaterial fabrication and characterization as well as in theoretical approaches in modeling and simulation. ? Section III, Applications, offers detailed examples of nanomaterial applications in alternative energy, thermal management, environmental cleanup, water treatment, and biomedicine. Each chapter has been written by one or more leading experts in the science, engineering, and application of nanomaterials. Within each chapter, readers will find a thorough review of the current literature, with references to facilitate further investigation of individual topics. Underscoring the multidisciplinary and multifunctional characteristics of nanomaterials, this book is recommended for students and professionals in science and engineering who need a broad perspective on both the nature and application of nanomaterials. The text also sets the stage for the development of new nanomaterials and new applications.