Найти книгу: "The Theory of Response-Adaptive Randomization in Clinical Trials"

Presents a firm mathematical basis for the use of response-adaptive randomization procedures in practice The Theory of Response-Adaptive Randomization in Clinical Trials is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these procedures. This timely book represents a mathematically rigorous subdiscipline of experimental design involving randomization and answers fundamental questions, including: How does response-adaptive randomization affect power? Can standard inferential tests be applied following response-adaptive randomization? What is the effect of delayed response? Which procedure is most appropriate and how can «most appropriate» be quantified? How can heterogeneity of the patient population be incorporated? Can response-adaptive randomization be performed with more than two treatments or with continuous responses? The answers to these questions communicate a thorough understanding of the asymptotic properties of each procedure discussed, including asymptotic normality, consistency, and asymptotic variance of the induced allocation. Topical coverage includes: The relationship between power and response-adaptive randomization The general result for determining asymptotically best procedures Procedures based on urn models Procedures based on sequential estimation Implications for the practice of clinical trials Useful for graduate students in mathematics, statistics, and biostatistics as well as researchers and industrial and academic biostatisticians, this book offers a rigorous treatment of the subject in order to find the optimal procedure to use in practice.

During the last decade, the martial arts world has looked to innovative mixed martial arts competitions such as the Ultimate Fighting Championship to determine which fighting style is the best. These contests have repeatedly shown the grappling style of martial arts, headed by Brazilian jiu-jitsu, to dominate. The Brazilian jiu-jitsu style stems from the premise, garnered from analysis of actual street fights, that the outcome of any fight is decided on the ground. While most martial arts deal only with the initial punching and kicking stages of combat, Brazilian jiu-jitsu concentrates on ground combat. This guide shows how to use Brazilian jiu-jitsu to increase combat effectiveness. Photographs and step-by-step instructions show how to master the techniques used in this exciting new form of combat. Renzo Gracie, a two-time world Abu Dhabi submission jiu-jitsu champion, two-time Brazilian national champion, World Combat champion, and Martial Arts Reality Superfight champion, teaches Brazilian jiu-jitsu at an elite martial arts academy. Royler Gracie has competed in the Black Belt ranks for 20 years, winning the world title four times and the Abu Dhabi world submission championship for two consecutive years. They live in New York City.

As part of the dynamics of international economic cooperation by the need for mutual settlement operations, so the problem of organization of settlements is an important place for the economically active subjects, especially in a globalized economic space in the functioning of transnational structures and scale of the export, import and international financial transactions. In agreeing on the order of calculations, the participants determined the form of payment in order to fulfill the financial obligations of the agreement – regulated by means of voluntary compliance through a credit institution liabilities, characterized by specific features on the order of transfer of funds to the account, a certain kind of settlement document, as well as office procedures. The source of payment relations is the need to have one contractor expressed in the appropriate disposition, the other in shortage. This relationship gives rise as a consequence of the relationship with the lending institution. Need to accession will intensify in the subjects of international payment relationship.

Полный вариант заголовка: «A treatise on mensuration : both in theory and practice / by Charles Hutton».

Time goes fast, new questions arise about human life, society, history, education, family, happiness… Old philosophy, old psychology have no instruments (concepts, methods, ideas) to answer these questions. New concepts like Levels-of-Mind model and Big-Triplet model plus minor models like Worlds-of-Life and Layers-of-Being wait you here. Use it to answers tough questions about the Time and the Life.