Найти книгу: "Kill as Directed"

Authored by one of the world's leading organic chemists, this authoritative reference provides an overview of basic strategies in directed evolution and introduces common gene mutagenesis, screening and selection methods. Throughout the text, emphasis is placed on methodology development to maximize efficiency, reliability and speed of the experiments and to provide guidelines for efficient protein engineering. Professor Reetz highlights the application of directed evolution experiments to address limitations in the field of enzyme selectivity, substrate scope, activity and robustness. He critically reviews recent developments and case studies, takes a look at future applications in the field of organic synthesis, and concludes with lessons learned from previous experiments.

The only book to present the synergy between modeling and simulation, systems engineering, and agent technologies expands the notion of agent-based simulation to also deal with agent simulation and agent-supported simulation. Accessible to both practitioners and managers, it systematically addresses designing and building agent systems from a systems engineering perspective.

Bringing together examples that until now were often hidden and widely spread throughout the original literature, this textbook shows how to use the correct reagents, conditions or reaction sequences to have access to all possible stereoisomers when beginning synthesis with only a single starting material. Adopting a didactic approach, the authors have chosen general and simple examples throughout the book so that these reactions can be transferred easily to other reaction types. While of major interest to master and PhD students alike, this book is also a source of valuable information for organic chemists in both academia and industry. Additional material for lectures at www.wiley-vch.de/textbooks

The Self-Directed Learning Handbook offers teachers and principals an innovative program for customizing schooling to the learning needs of individual students– and for motivating them to take increasing responsibility for deciding what and how they should learn. Whether the students are struggling or proficient, the program is designed to nurture their natural passion for learning and mastery, challenging them to go beyond the easy and familiar so they can truly excel. The program can be introduced in stages in any middle or high school classroom and enables students of diverse abilities to design and pursue independent course work, special projects, or even artistic presentations, community field work or apprenticeships. Using this approach, the students take on an increasingly autonomous, self-directed role as they progress. The heart of the program is the action contract (or learning agreement) whereby the student sets challenging yet attainable goals, commits to a path for achieving them, and evaluates the results. Special emphasis is placed on developing skills and competencies that can serve the student well in his or her academic and career endeavors.

“Directed by Desire . . . is a powerful addition to the entire canon of American poetry.”—Booklist Now in paperback, Directed by Desire is the definitive overview of June Jordan’s -poetry. Collecting the finest work from Jordan’s ten volumes, as well as dozens of “last poems” that were never published in Jordan’s lifetime, these more than six hundred pages overflow with intimate lyricism, elegance, fury, meditative solos, and dazzling vernacular riffs. As Adrienne Rich writes in her introduction, June Jordan “wanted her readers, listeners, students, to feel their own latent power—of the word, the deed, of their own beauty and intrinsic value.” From “These Poems”: These poems they are things that I do in the dark reaching for you whoever you are and are you ready? The cloth edition of Directed by Desire was selected as a Library Journal Poetry Book of the Year and received the Lambda Book Award for Lesbian Poetry. June Jordan taught at UC Berkeley for many years and founded Poetry for the People. Her twenty-eight books include poetry, essays, fiction, and children’s books. She was a regular columnist for The Progressive and a prolific writer whose articles appeared in The Village Voice, The New York Times, Ms. Magazine, and The Nation. After her death in 2002, a school in the San Francisco School District was renamed in her honor.