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RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.

A comprehensive reference to noise and signal interference in optical fiber communications Noise and Signal Interference in Optical Fiber Transmission Systems is a compendium on specific topics within optical fiber transmission and the optimization process of the system design. It offers comprehensive treatment of noise and intersymbol interference (ISI) components affecting optical fiber communications systems, containing coverage on noise from the light source, the fiber and the receiver. The ISI is modeled with a statistical approach, leading to new useful computational methods. The author discusses the subject with the help of numerous applications and simulations of noise and signal interference theory. Key features: Complete all-in-one reference on the subject for engineers and designers of optical fiber transmission systems Discusses the physical principles behind several noise contributions encountered in the optical communications systems design, including contributions from the light source, the fiber and the receiver Covers the theory of the ISI for the binary signal, as well as noise statistics Discusses the theory and the mathematical models of the numerous noise components (such as optical noise, photodetection noise and reflection noise) Introduces the frequency description of the ISI and provides new calculation methods based on the characteristic functions Provides useful tools and examples for optimum design of optical fiber transmission networks and systems This book will serve as a comprehensive reference for researchers, R & D engineers, developers and designers working on optical transmission systems and optical communications. Advanced students in optical communications and related fields will also find this book useful.

This hands-on guide to RNA interference brings the power of targeted gene silencing to any laboratory with the basic equipment for handling nucleic acids. In easy-to-follow, step-by-step protocols you will learn * how RNAi works in worms, flies and mammals, * how to design the most efficient RNAi constructs, * how to achieve transient, stable and conditional RNAi in cell cultures, * how to determine the efficiency of an RNAi experiment, * and how to use RNAi for gene therapy. All the protocols have been thoroughly tested in the author's own laboratory, and she provides examples of successful experiments and troubleshooting hints to help in establishing your own successful RNAi experiments. Also includes a list of suppliers for RNAi reagents and equipment as well as a glossary of terms.

Written by the department head of materials science and engineering at MIT, this concise and stringent introduction takes readers from the fundamental theory to in-depth knowledge. It sets out with a theoretical scheme for the design of desirable periodic structures, then presents the experimental techniques that allow for fabrication of the periodic structure and exemplary experimental data. Subsequently, theory and numerical data are used to demonstrate how these periodic structures control the photonic, acoustic, and mechanical properties of materials, concluding with examples from these three important fields of applications. The result is must-have knowledge for both beginners and veterans in the field.