Найти книгу: "Equilibria and Kinetics of Biological Macromolecules"

Progressively builds a deep understanding of macromolecular behavior Based on each of the authors' roughly forty years of biophysics research and teaching experience, this text instills readers with a deep understanding of the biophysics of macromolecules. It sets a solid foundation in the basics by beginning with core physical concepts such as thermodynamics, quantum chemical models, molecular structure and interactions, and water and the hydrophobic effect. Next, the book examines statistical mechanics, protein-ligand binding, and conformational stability. Finally, the authors address kinetics and equilibria, exploring underlying theory, protein folding, and stochastic models. With its strong emphasis on molecular interactions, Equilibria and Kinetics of Biological Macromolecules offers new insights and perspectives on proteins and other macromolecules. The text features coverage of: Basic theory, applications, and new research findings Related topics in thermodynamics, quantum mechanics, statistical mechanics, and molecular simulations Principles and applications of molecular simulations in a dedicated chapter and interspersed throughout the text Macromolecular binding equilibria from the perspective of statistical mechanics Stochastic processes related to macromolecules Suggested readings at the end of each chapter include original research papers, reviews and monographs, enabling readers to explore individual topics in greater depth. At the end of the text, ten appendices offer refreshers on mathematical treatments, including probability, computational methods, Poisson equations, and defining molecular boundaries. With its classroom-tested pedagogical approach, Equilibria and Kinetics of Biological Macromolecules is recommended as a graduate-level textbook for biophysics courses and as a reference for researchers who want to strengthen their understanding of macromolecular behavior.

The control of diseases in crops is still largely dominated by the use of fungicides, but with the increasing incidence of fungicide resistance, plus mounting concern for the environment resulting from excessive agrochemical use, the search for alternative, reliable methods of disease control is gaining momentum. The purpose of this important book is to examine the development and exploitation (or potential for exploitation) of a range of non-chemical approaches to disease control, with a focus on the need for a greater understanding of crop ecology as the basis for effective disease control in the field. Chapters in the book, written by international experts in the subject area, include coverage of: biological control methods host-plant resistance the exploitation of tolerance and the use of bacteriophages Carefully edited by Professor Dale Walters, widely respected for his work in the area of crop protection, Disease Control in Crops is an essential reference book for plant pathologists, microbiologists, plant and agricultural scientists and crop protection specialists, including those working within, and providing consultancy to, the agrochemical industries. Libraries in all universities and research establishments where biological sciences and agriculture are studied and taught should have copies of this timely publication on their shelves.

Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions and their inhibitors, and progressing to a thorough treatment of two-substrate enzymes, Kinetics of Enzyme Action: Essential Principles for Drug Hunters provides biochemists, medicinal chemists, and pharmaceutical scientists with numerous case study examples to outline the tools and techniques necessary to perform, understand, and interpret detailed kinetic studies for drug discovery.

This book is dedicated to the processes of mineral transformation, recycling and reclamation of metals, for the purpose of turning metals and alloys into a liquid state ready for pouring. Even though «process metallurgy» is one of the oldest technologies implemented by man, technological innovation, with the development of processes that are both focused on product quality and economically and ecologically efficient, continues to be at the heart of these industries. This book explains the physico-chemical bases of transformations, vital to their understanding and control (optimization of operational conditions), and the foundations in terms of «process engineering» (heat and matter assessment, process coupling: chemical reactions and transport phenomena), vital to the optimal execution and analysis of transformation process operations. This book is addressed to students in the field of metallurgy and to engineers facing the problem of metal and alloy development (operation of an industrial unit or development of a new process).

Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areas Electrospray and MALDI Mass Spectrometry brings both veteran practitioners and beginning scientists up to date with the most recent trends and findings in electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. In particular, this Second Edition highlights how advances in electrospray and MALDI mass spectrometry are supporting important discoveries in new and emerging fields such as proteomics and metabolomics as well as in traditional areas of chemistry and physics research. Electrospray AND MALDI Mass Spectrometry, SECOND EDITION is divided into five parts: Part A, Fundamentals of ES, explains the fundamental phenomena underlying the electrospray process, including selectivity in ionization and inherent electrochemistry, and concludes with a chapter offering a comparative inventory of source hardware Part B, Fundamentals of MALDI, confronts ionization mechanisms, instrument development, and matrix selection, and includes a final chapter that explores the special application of MALDI to obtain two-dimensional images of spatial distributions of compounds on surfaces Part C, ES and MALDI Coupling to Mass Spectrometry Instrumentation, examines the coupling of these ionization techniques to various mass analyzers, including quadrupole ion trap, time-of-flight, Fourier transform ion cyclotron resonance, and ion mobility mass spectrometers Part D, Practical Aspects of ES and MALDI, investigates analytical issues including quantification, charge-state distributions, noncovalent interactions in solution that are preserved as gas-phase ions, and various means of ion excitation in preparation for tandem mass spectrometry, and offers a guide to the interpretation of even-electron mass spectra Part E, Biological Applications of ES and MALDI, examines the role of mass spectrometry in such areas as peptide and protein characterization, carbohydrate analysis, lipid analysis, and drug discovery Written by a team of leading experts, the book not only provides a critical review of the literature, but also presents key concepts in tutorial fashion to help readers take full advantage of the latest technological breakthroughs and applications. As a result, Electrospray and MALDI Mass Spectrometry will help researchers fully leverage the power of electrospray and MALDI mass spectrometry. The judicious compartmentalization of chapters, and the pedagogic presentation style throughout, render the book highly suitable for use as a text for graduate-level courses in advanced mass spectrometry.

Auf Einladung der Deutschen Forschungsgemeinschaft (DFG) fand am 9. und 10. Marz 2000 ein Rundgesprach uber heutige und kunftige Moglichkeiten des Biomonitoring in Arbeits- und Umweltmedizin statt. Das Biomonitoring hat nicht zuletzt durch die unmittelbare Umsetzung der Arbeitsergebnisse der Senatskommission zur Prufung gesundheitsschadlicher Arbeitsstoffe in geltendes Recht durch die deutsche Arbeitsschutzgesetzgebung in den letzten drei?ig Jahren in Deutschland ein hohes Niveau erreicht. Das vorliegende Buch fuhrt die Expertise verschiedener Fachdisziplinen von der Toxikologie, Arbeitsmedizin, Immunologie und Humangenetik bis hin zur Analytik und Epidemiologie zusammen. Hierbei wird die diagnostische Aussagekraft von zytogenetischen Parametern sowie von biochemischen und biologischen Effektmarkern fur die Pravention von schadstoffbedingter Erkrankungen ausfuhrlich erortert. Das gefuhrte Rundgesprach hat somit einen ersten Gedankenaustausch ermoglicht, aus dem sich kunftige Forschung entwickeln soll, um die fuhrende Rolle Deutschlands auf diesem wichtigen und sich dynamisch entwickelnden Forschungsgebiet zu halten.