Найти книгу: "Peptidomimetics in Organic and Medicinal Chemistry"

A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.

Second edition, enlarged and revised with 215 color plates. This Thieme Flexibook presents the fundamentals of human and mammalian biochemistry in 192 stunning color plates. Key features include the unique combination of highly effective color graphics and comprehensive figure legends. Unified color-coding of atoms, coenzymes, chemical classes, and cell organelles allows quick recognition of all involved systems, and computer graphics provide simulated 3D representation of many important molecules. This Flexibook is ideal for students of all levels with its complete coverage of the structure and composition of biologically relevant molecules and their metabolism

Полный вариант заголовка: «A system of chemistry: in 5 volumes by Thomas Thomson Vol. 2».

Полный вариант заголовка: «A system of chemistry : Vol. 5 : in 5 volumes / by Thomas Thomson».

Полный вариант заголовка: «A system of chemistry : Vol. 1 : in 5 volumes / by Thomas Thomson».