Найти книгу: "Systems Biology in Drug Discovery and Development"

The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.

While the success of Open Source software like Linux or Apache has been documented extensively throughout all mainstream media, the rise of PHP has gone largely unnoticed. Still, the Web scripting language PHP is the most popular module for the Apache Web server, according to an E-Soft survey (www.e-softinc.com/survey/). Netcraft studies have found that PHP is in use on over 6% of all Web domains in the world (see www.netcraft.com/survey).That’s an incredible market penetration for a rather specialized product.This popularity continues to rise exponentially. Increasingly, this is being reflected in traditional media: As of May, 2000, more than 20 books about PHP have been published in different languages, with more in the pipeline. Commercial players are beginning to join the bandwagon: PHP is included with Web servers, for example C2’s Stronghold, and Linux distributions. A new company, Zend Technologies, has been formed to provide commercial add-ons and support for PHP.A long list of large-scale Web sites employ PHP, as well as hundreds of thousands of small to medium Web sites.

The personal home page (PHP) server-side scripting language is particular well adapted to connecting HTML-based web pages to a backend database for dynamic content. This book explains the entire nuts-and-bolts process of the PHP application life cycle: requirements, design, development, maintenance and tuning. It shows how PHP can be used to design and develop highly manageable and secure applications to solve practical problems.

This book will serve as an ideal guide to the relatively new and complex field of bioelectromagnetics for students and researchers interested in the interaction of biological systems and electromagnetic fields. Coverage details:(1) biological responses of human and animals, both in vivo and in vitro methodologies, to magnetic and/or electromagnetic field exposure, (2) characteristics of effective fields, (3) hypotheses to explain possible mechanisms of interaction between the fields and cells, and (4) induced current in ELF and induced heat in RF fields as key interaction mechanisms.

В книге содержится описание прикладной программы Simulink и библиотеки блоков SimPowerSystems, предназначенной для моделирования электротехнических устройств и систем. Рассматривается методика создания моделей с помощью графического интерфейса программы, описаны методы расчета моделей, подробно освещена методика создания электротехнических блоков пользователя. Даны основные команды для управления моделью из ядра пакета MATLAB, рассмотрен механизм выполнения расчета модели, приводятся советы автора по применению программы. Книга включает в себя большое количество примеров, поясняющих работу блоков и методику создания модели.

В книге содержится описание прикладной программы Simulink и библиотеки блоков SimPowerSystems, предназначенной для моделирования электротехнических устройств и систем. Рассматривается методика создания моделей с помощью графического интерфейса программы, описаны методы расчета моделей, подробно освещена методика создания электротехнических блоков пользователя. Даны основные команды для управления моделью из ядра пакета MATLAB, рассмотрен механизм выполнения расчета модели, приводятся советы автора по применению программы. Книга включает в себя большое количество примеров, поясняющих работу блоков и методику создания модели. Издание предназначено для инженеров, научных работников, аспирантов и студентов, занимающихся моделированием в области электротехники.