Найти книгу: "High-Throughput Screening Methods in Toxicity Testing"

Explores the benefits and limitations of the latest high-throughput screening methods With its expert coverage of high-throughput in vitro screening methods for toxicity testing, this book makes it possible for researchers to accelerate and streamline the evaluation and risk assessment of chemicals and drugs for toxicity. Moreover, it enables them to comply with the latest standards set forth by the U.S. National Research Council's «Toxicity Testing in the 21st Century: A Vision and Strategy» and the E.U.'s REACH legislation. Readers will discover a variety of state-of-the-science, high-throughput screening methods presented by a group of leading authorities in toxicology and toxicity testing. High-Throughput Screening Methods in Toxicity Testing is divided into five parts: General aspects, including predicting the toxicity potential of chemicals and drugs via high-throughput bioactivity profiling Assessing different cytotoxicity endpoints Assessing DNA damage and carcinogenesis Assessing reproductive toxicity, cardiotoxicity, and haematotoxicity Assessing drug metabolism and receptor-related toxicity Each chapter describes method principles and includes detailed information about data generation, data analysis, and applications in risk assessment. The authors not only enumerate the advantages of each high-throughput method over comparable conventional methods, but also point out the high-throughput method's limitations and potential pitfalls. In addition, the authors describe current research efforts to make high-throughput toxicity screening even more cost effective and streamlined. Throughout the book, readers will find plenty of figures and illustrations to help them understand and perform the latest high-throughput toxicity screening methods. This book is ideal for toxicologists and other researchers who need to implement high-throughput screening methods for toxicity testing in their laboratories as well as for researchers who need to evaluate the data generated by these methods.

Planning, preparing, scheduling, and executing SAP test cycles is a time-consuming and resource-intensive endeavor that requires participation from several project members. SAP projects are prone to have informal, ad-hoc test approaches that decrease the stability of the production environment and tend to increase the cost of ownership for the SAP system. Many SAP project and test managers cannot provide answers for questions such as how many requirements have testing coverage, the exit criteria for a test phase, the audit trails for test results, the dependencies and correct sequence for executing test cases, or the cost figures for a previously executed test cycle. Fortunately, through established testing techniques predicated on guidelines and methodologies (i.e., ASAP SAP Roadmap methodology, IBM’s Ascendant methodology, and Deloitte’s ThreadManager methodology), enforcement of standards, application of objective testing criteria, test case automation, implementation of a requirements traceability matrix (RTM), and independent testing and formation of centralized test teams, many of the testing risks that plague existing or initial SAP programs can be significantly reduced. This book is written for SAP managers, SAP consultants, SAP testers, and team leaders who are tasked with supporting, managing, implementing, and monitoring testing activities related to test planning, test design, test automation, test tool management, execution of test cases, reporting of test results, test outsourcing, planning a budget for testing activities, enforcing testing standards, and resolving defects.

Content

Introduction

Upholstery tools and materials

Manual dismantling of interior parts

Mastering the art of sewing

Making upholstery pattern

Examples of ready patterns

Covers

Installation instructions autocovers

Leather interior with their own hands

Padding of the saloon ceiling

We produce door skin

Padding vinyl interior

Padding upholstery motorcycle seats

Renovation of the old sagging armchair

Eliminating failures heated seat

Nano Textile upholstery

Technology smart car flocking

The interiors of the converted cars

Based on a set of four research parameters, this book discusses the development of research questions and hypotheses, naturalistic and experimental research, data collection, and validation of research instruments. Each chapter includes examples and activities.