Скачать книгу - Bacterial Pathogenesis

Addressing parasitic diseases and those caused by bacteria, this much needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.

Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA – quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes – sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis – aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis – ?-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

A valuable handbook containing reviews, practical methods and standard operating procedures. A valuable and practical working handbook containing introductory and specialist content that tackles a major and growing field of environmental, microbiological and ecotoxicological monitoring and analysis Includes introductory reviews, practical analytical chapters and a comprehensive listing of almost thirty Standard Operating Procedures (SOPs) For use in the laboratory, in academic and government institutions and industrial settings

Рассматривается решение оптимизационной задачи продвижения инновационных проектов в регионы с применением комплексной имитационной модели с включением в ее состав модулей бактериальной оптимизации. В качестве объекта исследования выбран процесс формирования инновационного кластера. Комплексная модель выполнена в моделирующей системе «Actor Pilgrim» с реализацией временнoй, пространственной и финансовой динамики (деньги, финансовые инструменты) в едином виртуальном времени. Результаты моделирования привязаны к топографической информации различных масштабов.

This much-anticipated third edition again consolidates the knowledge of more than twenty experts on pathogenesis of animal disease caused by various species or groups of bacteria. Emphasizing pathogenic events at the molecular and cellular levels, the editors and contributors place these developments in the context of the overall picture of disease. Pathogenesis of Bacterial Infections in Animals, Third edition, updates and expands the content of the second edition and includes cutting-edge information from the most current research. Comments on previous editions: «…highly recommended.» –The Veterinary Record «…a comprehensive, complete and easy-to-use source of information.» –Veterinary Microbiology «…recommended for graduate students and specialists in microbiology, pathology and infectious disease.» –U.S. Animal Health Association Newsletter «…a wonderful book.» –Journal of the American Veterinary Medical Association «…highly recommended.» –The Cornell Veterinarian Graduate students, faculty, researchers, and specialists in microbiology, pathology, and infectious diseases will benefit from this highly-detailed and expanded edition of a popular and well-read veterinary text.