Скачать книгу - Integrated Strategies for Drug Discovery Using Mass Spectrometry



New strategies and techniques for today's fast-paced discovery process Today, the pressure is on for high-throughput approaches to accelerate the generation, identification, and optimization of molecules with desirable drug properties. As traditional methods of analysis become antiquated, new analytical strategies and techniques are necessary to meet sample throughput requirements and manpower constraints. Among them, mass spectrometry has grown to be a front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometry provides a thorough review of current analytical approaches, industry practices, and strategies in drug discovery. The topics represent current industry benchmarks in specific drug discovery activities that deal with proteomics, biomarker discovery, metabonomic approaches for toxicity screening, lead identification, compound libraries, quantitative bioanalytical support, biotransformation, reactive metabolite characterization, lead optimization, pharmaceutical property profiling, sample preparation strategies, and automation. THIS BOOK: * Clearly explains how drug discovery and mass spectrometry are interconnected * Discusses the uses and limitations of various types of mass spectrometry in various aspects of drug discovery * Prominently features analytical applications that require trace-mixture analysis * Provides industry applications and real-world examples * Shares historical background information on various techniques to aid in the understanding of how and why new methods are now being employed to analyze samples


Photoshop CS2 Raw: Using Adobe Camera Raw, Bridge, and Photoshop to Get the Most Out of Your Digital Camera Photoshop CS2 Raw: Using Adobe Camera Raw, Bridge, and Photoshop to Get the Most Out of Your Digital Camera

Автор: Aaland Mikkel

Год издания: 

The RAW file format is the uncompressed data file captured by a digital camera's electronic sensor. When your camera saves an image in RAW format, settings like white balance, sharpening, contrast and saturation are not applied to the image but are saved instead in a separate header. Because RAW files remain virtually untouched by in-camera processing, they are essentially the digital equivalent to exposed but undeveloped film. This makes RAW an increasingly popular format with amateur and professional digital photographers, because it affords greater flexibility and control during the editing process-if you know how to work with RAW files. Most digital camera manufacturers supply their own software for converting RAW data, as do some third party vendors. Increasingly, however, the RAW converter of choice is a plug-in included in the latest version of Adobe Photoshop, the most popular and widely-used digital image editing tool in the world. Adobe Photoshop CS2 is emerging as the best place to edit RAW images, and the best way to master this new format is with Photoshop CS2 RAW. An important book dedicated to working with RAW in Photoshop, this comprehensive guide features a unique design that helps readers grasp the subject through visual instruction and prompts. The entire RAW process is explored, from shooting to using the Adobe plug-in converter and new Bridge navigation software. The primary focus of Photoshop RAW is, as the title suggests, Photoshop editing technique: automating RAW workflow, correcting exposures, extending exposure range, manipulating grayscale and working with the new DNG (Digital Negative) open standard that Adobe supports. Presented by photographer Mikkel Aaland, a pioneer of digital photography and author of eight books, including O"Reilly"s Photoshop for the Web and the award-winning Shooting Digital, Photoshop CS2 RAW investigates and instructs in an accessible visual style. Required reading for professionals and dedicated photo hobbyists alike.


Proceedings of the Association for promoting the discovery of the interior parts of Africa Proceedings of the Association for promoting the discovery of the interior parts of Africa

Автор: Группа авторов

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The history of the discovery and conquest of the Canary Islands The history of the discovery and conquest of the Canary Islands

Автор: George Glas

Год издания: 

Полный вариант заголовка: «The history of the discovery and conquest of the Canary Islands : translated from a Spanish manuscript, lately found in the island of Palma : with an enquiry into the origin of the ancient inhabitants : to which is added, a dsescription of the Canary Islands, including the modern history of the inhabitants, and an account of their manners, customs, trade, & c. / by George Glas».


Developing Strategies in Reading Comprehension / Английский язык. Стратегии понимания текста. Часть 1 Developing Strategies in Reading Comprehension / Английский язык. Стратегии понимания текста. Часть 1

Автор: Е. Б. Карневская

Год издания: 



Developing Strategies in Reading Comprehension / Английский язык. Стратегии понимания текста. Часть 2 Developing Strategies in Reading Comprehension / Английский язык. Стратегии понимания текста. Часть 2

Автор: Е. Б. Карневская

Год издания: