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Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections is a complete examination of the ways in which proteins with more than one unique biological action are able to serve as virulence factors in different bacteria. The book explores the pathogenicity of bacterial moonlighting proteins, demonstrating the plasticity of protein evolution as it relates to protein function and to bacterial communication. Highlighting the latest discoveries in the field, it details the approximately 70 known bacterial proteins with a moonlighting function related to a virulence phenomenon. Chapters describe the ways in which each moonlighting protein can function as such for a variety of bacterial pathogens and how individual bacteria can use more than one moonlighting protein as a virulence factor. The cutting-edge research contained here offers important insights into many topics, from bacterial colonization, virulence, and antibiotic resistance, to protein structure and the therapeutic potential of moonlighting proteins. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections will be of interest to researchers and graduate students in microbiology (specifically bacteriology), immunology, cell and molecular biology, biochemistry, pathology, and protein science. About the Editor Brian Henderson, Division of Infection and Immunity, University College London, London, UK

The past 25 years has seen the emergence of a wealth of data suggesting that novel biological functions of known proteins play important roles in biology and medicine. This ability of proteins to exhibit more than one unique biological activity is known as protein moonlighting. Moonlighting proteins can exhibit novel biological functions, thus extending the function of the proteome, and are also implicated in the pathology of a growing number of idiopathic and infectious diseases. This book, written by a cell biologist, protein evolutionary biologist and protein bioinformatician, brings together the latest information on the structure, evolution and biological function of the growing numbers of moonlighting proteins that have been identified, and their roles in human health and disease. This information is revealing the enormous importance protein moonlighting plays in the maintenance of human health and in the induction of disease pathology. Protein Moonlighting in Biology and Medicine will be of interest to a general readership in the biological and biomedical research community.

A groundbreaking account of what it was like to live in a Victorian body from one of our best historians, author of The Short Life and Long Times of Mrs Beeton and George Eliot: The Last Victorian.Why did the great philosophical novelist George Eliot feel so self-conscious that her right hand was larger than her left?Exactly what made Darwin grow that iconic beard in 1862, a good five years after his contemporaries had all retired their razors?Who knew Queen Victoria had a personal hygiene problem as a young woman and the crisis that followed led to a hurried commitment to marry Albert?What did John Sell Cotman, a handsome drawing room operator who painted some of the most exquisite watercolours the world has ever seen, feel about marrying a woman whose big nose made smart people snigger?How did a working-class child called Fanny Adams disintegrate into pieces in 1867 before being reassembled into a popular joke, one we still reference today, but would stop, appalled, if we knew its origins?Kathryn Hughes follows a thickened index finger or deep baritone voice into the realms of social history, medical discourse, aesthetic practise and religious observance – its language is one of admiring glances, cruel sniggers, an implacably turned back. The result is an eye-opening, deeply intelligent, groundbreaking account that brings the Victorians back to life and helps us understand how they lived their lives.

A Tangled Web by Mercedes LackeyKidnapping Persephone should have been easy. But in the Five Hundred Kingdoms, nothing's ever simple–and the wrong goddess is stolen by mistake, leaving Prince Leopold without his new bride. At least until he braves the realm of the dead to get her back…Cast in Moonlight by Michelle SagaraBarely a teenager, Kaylin Neya is a thief, fugitive and attempted assassin. She also has a smart mouth, sharp wits and mysterious markings on her skin. All of which make her perfect bait for a child prostitution sting in the city of Elantra–if she survives her first meeting with the Hawks! Retribution by Cameron Haley In the underworld, there are tricks to killing. Like executing rivals at crossroads so ghosts won't follow you home. But sometimes retribution is hard to avoid–and now a supernatural hit man has a contract on Domino Riley's life. Luckily she knows a thing or two about death…