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Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications. Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers: In vivo imaging techniques and quantitative analysis Imaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticles Applications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral delivery Translational research leading to clinical applications Imaging drug delivery in large animal models Clinical applications of imaging techniques to guide drug development and drug delivery Chapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems. Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.

Minimally Invasive Dental Implant Surgery presents a new clinical text and atlas focused on cutting edge and rapidly developing, minimally invasive treatment modalities and their applications to implant dentistry. Centered on progress in imaging, instrumentation, biomaterials and techniques, this book discusses both the “how to” as well as the “why” behind the concept of minimally invasive applications in implant surgery. Drawing together key specialists for each topic, the book provides readers with guidance for a broad spectrum of procedures, and coalesces information on the available technologies into one useful resource. Minimally Invasive Dental Implant Surgery will be a useful new guide to implant specialists and restorative dentists seeking to refine their clinical expertise and minimize risk for their patients.

A funny, magical, colourful story collection for young children.The stories are:• Serena and the Sea Serpent – in which a small girl discovers that being a Penguinmaid is too much fun!• Bill the Inventor – in which a young orphan discovers that finding ideal parents is very tricky indeed!• Blackbread the Pirate – in which Peter discovers that the world beneath his feet is fraught with rude rats!• The Princess and the Beastly Beast – in which Rinda discovers that monsters are not always so terrible on the inside…Garth Nix takes on a younger audience with this collection of magical adventures. His trademark fertile imagination and spellbinding storytelling is sure to capture a whole new generation of fans.

Arizona. 1873. The ultimate showdown between cowboys and Indians is interrupted… by an alien invasion.Every conqueror believes himself moved by a higher power, his destructive actions justified by necessity, compassion, or divine providence. In the greatest and most deadly expansion the world has seen, European settlers pushed west, decimating the native population without a second thought. But when aliens invade, they give the cowboys the fight of their lives, forcing them to pair with the Indians in a battle for control of the planet.The Old West will never be the same…“Cowboys and Aliens” is the graphic novel on which the major movie starring Daniel Craig and Harrison Ford is based.