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Some drugs which are not aimed at treating heart disease have nevertheless been found to have profound effects on heart muscle. Cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals.In recent years a number of non-cardiac blockbuster drugs such as terfenadine have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been withdrawn prior to marketing or required labelling changes that significantly restricted their use. In Cardiotoxicity of Non-Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Particular emphasis is paid to the preclinical screening of drug cardiotoxicity. Topics include: metabolic targets of cardiotoxicity regulatory aspects translating molecular mechanisms into clinical trials structure-activity relationships in arrhythmias by antihistamines and psychoactive drugs cardiovascular toxicity of antitumor drugs cardiovascular toxicities of non-steroidal anti-inflammatory drugs cardiovascular toxicities of antiretroviral therapies Cardiotoxicity of Non-Cardiovascular Drugs is an essential guide to this important area of drug development. It will find a place on the bookshelves of researchers, regulators and students in medicinal chemistry, drug development, pharmacology, pharmacy and cardiovascular disease.

The relationship of metabolic diseases to cardiovascular disease (CVD) is reaching epidemic proportions. This relates mostly to the increasing prevalence of obesity, the metabolic syndrome and type 2 diabetes. This book outlines and addresses the metabolic factors and related diseases that contribute to CVD, including brief introductions to metabolic pathways including lipid and lipoprotein metabolism, macronutrient fuel partitioning, insulin action and body weight regulation. Mechanisms that relate to becoming obese, maintenance of the obese state, the dyslipidemias, and glucose intolerance/diabetes are also addressed, and the importance of interventions that reduce metabolic risk factors and CVD are covered.

This comprehensive and concise presentation of genetic factors in cardiovascular disease and their response to therapy consolidates knowledge of this high-interest and emerging topic. Covering broad areas of contemporary genomic medicine and specific cardiovascular diseases, this book is a must for anyone seeking to better understand this rapidly developing field.

Diabetic Foot Care: Case Studies in Clinical Management uses a 100% illustrated patient case study format to demonstrate the multidisciplinary care and clinical management of patients with feet and lower limb problems as a result of diabetes. Every case has colour illustrations highlighting both the initial presentation of the foot, right through to treatment and long term follow-up care. Of particular focus are the management problems, barriers to effective care, preventable mistakes, unnecessary delays in presentations, challenging situations, conflicts, dilemmas and solutions that podiatrists and diabetic specialists face. Sections in the book include: Neuropathic and neuroischaemic foot, neuropathic ulcers, ischaemic ulcers, infections, gangrene, traumatic injuries, Charcot's osteoarthropathy, dermatological problems associated with diabetes, painful neuropathy, diabetic foot emergencies, angiology and foot surgery/amputation. With key points and summaries at the beginning and end of each section, this book is clear and easy to navigate, making it an ideal tool for diabetes specialists, diabetes nurses and podiatrists.

Foot problems in diabetic patients are some of the most challenging complications to treat, due to an often quite late presentation of symptoms from the patient. Therefore visual recognition of presenting clinical signs is absolutely key for a successful diagnosis and subsequently, the right management programme. The 3rd edition of Managing the Diabetic Foot once again provides a practical, handy and accessible pocket guide to the clinical management of patients with severe feet problems associated with diabetes, such as ulcers, infections and necrosis. By focusing on the need for a speedy response to the clinical signs, it will enable doctors make rapid, effective management decisions in order to help prevent deterioration and avoid the need for evental foot amputation. Each chapter focuses specifically on the different stages of foot disease and the clinical management required at that particular stage, ie, the normal foot; high-risk foot, ulcerated foot, infected foot, necrotic foot and unsalvageable foot. Full colour throughout, it will feature over 150 clinical photos, numerous hints and tips to aid rapid-reference, as well as the latest national and international guidelines on diabetic foot management. Managing the Diabetic Foot, 3E, is the ideal go-to clinical tool for all diabetes professionals, specialist diabetes nurses and podiatrists managing patients with diabetic foot problems.