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This important revision presents the accumulated knowledge of its highly-regarded author, Dr. Abraham Rudolph, who is internationally recognized as one of the world's leading pioneers in the field of Pediatric Cardiology. Fully revised and updated, the book includes sections considering the changes in pathophysiology with growth into adulthood and the effects of various treatment approaches. The author explains the physiology of normal fetal circulation and the effects of congenital cardiac lesions, with particular reference to the interactions between the lesions and fetal cardiovascular development.

An important feature of this book is the particular combination of topics included. These are (1) control, (2) navigation and (3) remote sensing, all with application to mobile robots. Much of the material is readily extended to any type ground vehicle. In the controls area, robot steering is the issue. Both linear and nonlinear models are treated. Various control schemes are utilized, and through these applications the reader is introduced to methods such as: (1) Linearization and use of linear control design methods for control about a reference trajectory, (2) Use of Lyapunov stability theory for nonlinear control design, (3) Derivation of optimal control strategies via Pontryagin’s maximum principle, (4) Derivation of a local coordinate system which is fundamental for the steering of vehicles along a path never before traversed. This local coordinate system has application regardless of the control design methods utilized. In the navigation area, various coordinate systems are introduced, and the transformations among them are derived. (1) The Global Positioning System (GPS) is introduced and described in significant detail. (2) Also introduced and discussed are inertial navigation systems (INS). These two methods are treated in terms of their ability to provide vehicle position as well as attitude. A preceding chapter is devoted to coordinate rotations and transformations since they play an important role in the understanding of this body of theory.

Urban Remote Sensing is designed for upper level undergraduates, graduates, researchers and practitioners, and has a clear focus on the development of remote sensing technology for monitoring, synthesis and modeling in the urban environment. It covers four major areas: the use of high-resolution satellite imagery or alternative sources of image date (such as high-resolution SAR and LIDAR) for urban feature extraction; the development of improved image processing algorithms and techniques for deriving accurate and consistent information on urban attributes from remote sensor data; the development of analytical techniques and methods for deriving indicators of socioeconomic and environmental conditions that prevail within urban landscape; and the development of remote sensing and spatial analytical techniques for urban growth simulation and predictive modeling.

The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but without one dedicated book that provides the information researchers need to learn these new techniques, its applications are severely limited. Describing the principles, methods, and applications of PBPK modeling as used in pharmaceutics, Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations fills this void. Connecting theory with practice, the book explores the incredible potential of PBPK modeling for improving drug discovery and development. Comprised of two parts, the book first provides a detailed and systematic treatment of the principles behind physiological modeling of pharmacokinetic processes, inter-individual variability, and drug interactions for small molecule drugs and biologics. The second part looks in greater detail at the powerful applications of PBPK to drug research. Designed for a wide audience encompassing readers looking for a brief overview of the field as well as those who need more detail, the book includes a range of important learning aids. Featuring end-of-chapter keywords for easy reference—a valuable asset for general or novice readers without a PBPK background—along with an extensive bibliography for those looking for further information, Physiologically- Based Pharmacokinetic (PBPK) Modeling and Simulations is the essential single-volume text on one of the hottest topics in the pharmaceutical sciences today.