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The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting attention in the design and delivery of a therapeutic protein, exposes analytical challenges that may occur when characterizing these molecules, and presents a number of tested solutions. The first single-volume guide of its kind, Analytical Characterization of Biotherapeutics brings together contributions from scientists at the leading edge of biotherapeutics research and manufacturing. Key topics covered in-depth include the structural characterization of recombinant proteins and antibodies, antibody de novo sequencing, characterization of antibody drug conjugates, characterization of bi-specific or other hybrid molecules, characterization of manufacturing host-cell contaminant proteins, analytical tools for biologics molecular assessment, and more. Each chapter is written by a recognized expert or experts in their field who discuss current and cutting edge approaches to fully characterizing biotherapeutic proteins and antigen reagents Covers the full range of characterization strategies for large molecule based therapeutics Provides an up-to-date account of the latest approaches used for large molecule characterization Chapters cover the background needed to understand the challenges at hand, solutions to characterize these large molecules, and a summary of emerging options for analytical characterization Analytical Characterization of Biotherapeutics is an up-to-date resource for analytical scientists, biologists, and mass spectrometrists involved in the analysis of biomolecules, as well as scientists employed in the pharmaceuticals and biotechnology industries. Graduate students in biology and analytical science, and their instructors will find it to be fascinating and instructive supplementary reading. Получить ссылку |
Analytical Studies
Автор: Оноре де Бальзак
Год издания:
Heuristics in Analytics. A Practical Perspective of What Influences Our Analytical World
Автор: Fiona McNeill
Год издания:
Employ heuristic adjustments for truly accurate analysis Heuristics in Analytics presents an approach to analysis that accounts for the randomness of business and the competitive marketplace, creating a model that more accurately reflects the scenario at hand. With an emphasis on the importance of proper analytical tools, the book describes the analytical process from exploratory analysis through model developments, to deployments and possible outcomes. Beginning with an introduction to heuristic concepts, readers will find heuristics applied to statistics and probability, mathematics, stochastic, and artificial intelligence models, ending with the knowledge applications that solve business problems. Case studies illustrate the everyday application and implication of the techniques presented, while the heuristic approach is integrated into analytical modeling, graph analysis, text analytics, and more. Robust analytics has become crucial in the corporate environment, and randomness plays an enormous role in business and the competitive marketplace. Failing to account for randomness can steer a model in an entirely wrong direction, negatively affecting the final outcome and potentially devastating the bottom line. Heuristics in Analytics describes how the heuristic characteristics of analysis can be overcome with problem design, math and statistics, helping readers to: Realize just how random the world is, and how unplanned events can affect analysis Integrate heuristic and analytical approaches to modeling and problem solving Discover how graph analysis is applied in real-world scenarios around the globe Apply analytical knowledge to customer behavior, insolvency prevention, fraud detection, and more Understand how text analytics can be applied to increase the business knowledge Every single factor, no matter how large or how small, must be taken into account when modeling a scenario or event—even the unknowns. The presence or absence of even a single detail can dramatically alter eventual outcomes. From raw data to final report, Heuristics in Analytics contains the information analysts need to improve accuracy, and ultimately, predictive, and descriptive power.
Mortgage-Backed Securities. Products, Structuring, and Analytical Techniques
Автор: Frank J. Fabozzi
Год издания:
An up-to-date look at the latest innovations in mortgage-backed securities Since the last edition of Mortgage-Backed Securities was published over three years ago, much has changed in the structured credit market. Frank Fabozzi, Anand Bhattacharya, and William Berliner all have many years of experience working in the fixed-income securitization markets, and have witnessed many cycles of change in the mortgage and MBS sectors. And now, with the Second Edition of Mortgage-Backed Securities, they share their knowledge on many of the products and structuring innovations that have taken place since the financial crisis and fiscal reform. Written in a straightforward and accessible style, and containing numerous illustrations, this timely guide skillfully addresses the investment characteristics, creation, and analysis of mortgage-backed securities. Each chapter contains cutting-edge concepts that you'll need to understand in order to thrive within this arena. Discusses the dynamic interaction between the mortgage industry, home prices, and credit performance Addresses revised valuation techniques in which all non-agency MBS must be treated as credit pieces Examines the shift in this marketplace since the crisis and the impact on industry and investors Filled with in-depth insights and expert advice, Mortgage-Backed Securities, Second Edition offers you a realistic assessment of this field and outlines the products, structures, and analytical techniques you need to know about in this evolving arena.
Nanoscale CMOS. Innovative Materials, Modeling and Characterization
Автор: Francis Balestra
Год издания:
This book provides a comprehensive review of the state-of-the-art in the development of new and innovative materials, and of advanced modeling and characterization methods for nanoscale CMOS devices. Leading global industry bodies including the International Technology Roadmap for Semiconductors (ITRS) have created a forecast of performance improvements that will be delivered in the foreseeable future – in the form of a roadmap that will lead to a substantial enlargement in the number of materials, technologies and device architectures used in CMOS devices. This book addresses the field of materials development, which has been the subject of a major research drive aimed at finding new ways to enhance the performance of semiconductor technologies. It covers three areas that will each have a dramatic impact on the development of future CMOS devices: global and local strained and alternative materials for high speed channels on bulk substrate and insulator; very low access resistance; and various high dielectric constant gate stacks for power scaling. The book also provides information on the most appropriate modeling and simulation methods for electrical properties of advanced MOSFETs, including ballistic transport, gate leakage, atomistic simulation, and compact models for single and multi-gate devices, nanowire and carbon-based FETs. Finally, the book presents an in-depth investigation of the main nanocharacterization techniques that can be used for an accurate determination of transport parameters, interface defects, channel strain as well as RF properties, including capacitance-conductance, improved split C-V, magnetoresistance, charge pumping, low frequency noise, and Raman spectroscopy.
Field Computation for Accelerator Magnets. Analytical and Numerical Methods for Electromagnetic Design and Optimization
Автор: Stephan Russenschuck
Год издания:
Written by a leading expert on the electromagnetic design and engineering of superconducting accelerator magnets, this book offers the most comprehensive treatment of the subject to date. In concise and easy-to-read style, the author lays out both the mathematical basis for analytical and numerical field computation and their application to magnet design and manufacture. Of special interest is the presentation of a software-based design process that has been applied to the entire production cycle of accelerator magnets from the concept phase to field optimization, production follow-up, and hardware commissioning. Included topics: Technological challenges for the Large Hadron Collider at CERN Algebraic structures and vector fields Classical vector analysis Foundations of analytical field computation Fields and Potentials of line currents Harmonic fields The conceptual design of iron- and coil-dominated magnets Solenoids Complex analysis methods for magnet design Elementary beam optics and magnet polarities Numerical field calculation using finite- and boundary-elements Mesh generation Time transient effects in superconducting magnets, including superconductor magnetization and cable eddy-currents Quench simulation and magnet protection Mathematical optimization techniques using genetic and deterministic algorithms Practical experience from the electromagnetic design of the LHC magnets illustrates the analytical and numerical concepts, emphasizing the relevance of the presented methods to a great many applications in electrical engineering. The result is an indispensable guide for high-energy physicists, electrical engineers, materials scientists, applied mathematicians, and systems engineers.
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