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Discover an enhanced synthetic approach to developing and screening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology. Diversity-Oriented Synthesis begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis by describing chemical libraries Provides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assays Presents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical research This book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications. Clearly written and extensively referenced, Diversity-Oriented Synthesis introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications. Получить ссылку |
A Diversity of Creatures
Автор: Редьярд Джозеф Киплинг
Год издания:
The Human Equity Advantage. Beyond Diversity to Talent Optimization
Автор: Trevor Wilson
Год издания:
A fresh approach to the old problem of «diversity fatigue» Trevor Wilson, global diversity strategist and visionary leader, presents a fresh, new management model that goes beyond the traditional diversity debate towards inclusion and building human capital. Featuring case studies and practical diagnostic tools and assessments, this book will benefit anyone who is interested in improving their business by building on the unique talents of employees' innate strengths, unique abilities, personality, attitude, life experience and virtues. The agent of this change, the driver of the process, is the equitable leader. This important book outlines 8 core competencies that will guide leaders to create equitable and inclusive work environments where employees are valued because of, not in spite of, their differences and each person can be recognized and developed to strive for their highest potential. Includes a new paradigm for diversity initiatives and finds new solutions Reveals the core competencies that help leaders create an equitable and inclusive workplace Shows how companies can improve hiring and retention, reduce turnover, increase productivity, improve teamwork, and ultimately increase the bottom line The Human Equity Advantage gives you the tools to tap into the unique talents and strengths of each employee.
Beginning Java Programming. The Object-Oriented Approach
Автор: Bart Baesens
Год издания:
A comprehensive Java guide, with samples, exercises, case studies, and step-by-step instruction Beginning Java Programming: The Object Oriented Approach is a straightforward resource for getting started with one of the world's most enduringly popular programming languages. Based on classes taught by the authors, the book starts with the basics and gradually builds into more advanced concepts. The approach utilizes an integrated development environment that allows readers to immediately apply what they learn, and includes step-by-step instruction with plenty of sample programs. Each chapter contains exercises based on real-world business and educational scenarios, and the final chapter uses case studies to combine several concepts and put readers' new skills to the test. Beginning Java Programming: The Object Oriented Approach provides both the information and the tools beginners need to develop Java skills, from the general concepts of object-oriented programming. Learn to: Understand the Java language and object-oriented concept implementation Use Java to access and manipulate external data Make applications accessible to users with GUIs Streamline workflow with object-oriented patterns The book is geared for those who want to use Java in an applied environment while learning at the same time. Useful as either a course text or a stand-alone self-study program, Beginning Java Programming is a thorough, comprehensive guide.
SOA Modeling Patterns for Service Oriented Discovery and Analysis
Автор: Michael Bell
Год издания:
Learn the essential tools for developing a sound service-oriented architecture SOA Modeling Patterns for Service-Oriented Discovery and Analysis introduces a universal, easy-to-use, and nimble SOA modeling language to facilitate the service identification and examination life cycle stage. This business and technological vocabulary will benefit your service development endeavors and foster organizational software asset reuse and consolidation, and reduction of expenditure. Whether you are a developer, business architect, technical architect, modeler, business analyst, team leader, or manager, this essential guide-introducing an elaborate set of more than 100 patterns and anti-patterns-will help you successfully discover and analyze services, and model a superior solution for your project,. Explores how to discover services Explains how to analyze services for construction and production How to assess service feasibility for deployment How to employ the SOA modeling language during the service identification and examination process How to utilize the SOA modeling patterns and anti-patterns for service discovery and analysis Focusing on the Service-Oriented Discovery and Analysis Life Cycle Stage, this book will help you acquire a broad SOA Modeling knowledge base and leverage that to increase efficiency and productivity in the workplace.
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