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Focuses on the aggregation of recombinant proteins in bacterial cells in the form of inclusion bodies—and on their use in biotechnological and medical applications The first book devoted specifically to the topic of aggregation in bacteria, Protein Aggregation in Bacteria: Functional and Structural Properties of Inclusion Bodies in Bacterial Cells provides a large overview of protein folding and aggregation, including cell biology and methodological aspects. It summarizes, for the first time in one book, ideas and technical approaches that pave the way for a direct use of inclusion bodies in biotechnological and medical applications. Protein Aggregation in Bacteria covers: Molecular and cellular mechanisms of protein folding, aggregation, and disaggregation in bacteria Physiological importance and consequences of aggregation for the bacterial cell Factors inherent to the protein sequence responsible for aggregation and evolutionary mechanisms to keep proteins soluble Structural properties of proteins expressed as soluble aggregates and as inclusion bodies within bacterial cells both from a methodological point of view and with regard to their similarity with amyloids Control of the structural and functional properties of aggregated proteins and use thereof in biotechnology and medicine Protein Aggregation in Bacteria is ideal for researchers in protein science, biochemistry, bioengineering, biophysics, microbiology, medicine, and biotechnology, particularly if they are related with the production of recombinant proteins and pharmaceutical science.


Bacteria in Daily Life Bacteria in Daily Life

Автор: Frankland Grace C.

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Data Mining for Genomics and Proteomics. Analysis of Gene and Protein Expression Data Data Mining for Genomics and Proteomics. Analysis of Gene and Protein Expression Data

Автор: Darius Dziuda M.

Год издания: 

Data Mining for Genomics and Proteomics uses pragmatic examples and a complete case study to demonstrate step-by-step how biomedical studies can be used to maximize the chance of extracting new and useful biomedical knowledge from data. It is an excellent resource for students and professionals involved with gene or protein expression data in a variety of settings.


Discover the World of Microbes. Bacteria, Archaea, Viruses Discover the World of Microbes. Bacteria, Archaea, Viruses

Автор: Gerhard Gottschalk

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This title is an essential primer for all students who need some background in microbiology and want to become familiar with the universal importance of bacteria for all forms of life. Written by Gerhard Gottschalk, Fellow of the American Academy of Microbiology and one of the most prominent microbiologists in our time, this text covers the topic in its whole breadth and does not only focus on bacteria as pathogens. The book is written in an easy-to-read, entertaining style but each chapter also contains a `facts' section with compact text and diagrams for easy learning. In addition, more than 40 famous scientists, including several Nobel Prize winners, contributed sections, written specifically for this title. The book comes with color figures and a companion website with questions and answers. Key features: Unique, introductory text offering a comprehensive overview of the astonishing variety and abilities of Bacteria Easy-to-read, fascinating and educational Written by one of the best known microbiologists of our time Color images throughout Each chapter has a compact tutorial part with schemes on the biochemistry and metabolic pathways of Bacteria Comes with a companion website with questions and answers


Antiparasitic and Antibacterial Drug Discovery. From Molecular Targets to Drug Candidates Antiparasitic and Antibacterial Drug Discovery. From Molecular Targets to Drug Candidates

Автор: Paul Selzer M.

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Addressing parasitic diseases and those caused by bacteria, this much needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.


Proteins. Biochemistry and Biotechnology Proteins. Biochemistry and Biotechnology

Автор: Gary Walsh

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Proteins Biochemistry and Biotechnology 2e is a definitive source of information for all those interested in protein science, and particularly the commercial production and isolation of specific proteins, and their subsequent utilization for applied purposes in industry and medicine. Fully updated throughout with new or fundamentally revised sections on proteomics as, bioinformatics, protein glycosylation and engineering, well as sections detailing advances in upstream processing and newer protein applications such as enzyme-based biofuel production this new edition has an increased focus on biochemistry to ensure the balance between biochemisty and biotechnology, enhanced with numerous case studies. This second edition is an invaluable text for undergraduates of biochemistry and biotechnology but will also be relevant to students of microbiology, molecular biology, bioinformatics and any branch of the biomedical sciences who require a broad overview of the various medical, diagnostic and industrial uses of proteins. • Provides a comprehensive overview of all aspects of protein biochemisty and protein biotechnology • Includes numerous case studies • Increased focus on protein biochemistry to ensure balance between biochemisty and biotechnology • Includes new section focusing on proteomics as well as sections detailing protein function and enzyme-based biofuel production "With the potential of a standard reference source on the topic, any molecular biotechnologist will profit greatly from having this excellent book. « (Engineering in Life Sciences, 2004; Vol 5; No. 5) “Few texts would be considered competitors, and none compare favorably.» (Biochemistry and Molecular Education, July/August 2002) «…The book is well written, making it informative and easy to read…» (The Biochemist, June 2002)