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This book introduces theoretical concepts to explain the fundamentals of the design and evaluation of software estimation models. It provides software professionals with vital information on the best software management software out there. End-of-chapter exercises Over 100 figures illustrating the concepts presented throughout the book Examples incorporated with industry data

Presents inference and simulation of stochastic process in the field of model calibration for financial times series modelled by continuous time processes and numerical option pricing. Introduces the bases of probability theory and goes on to explain how to model financial times series with continuous models, how to calibrate them from discrete data and further covers option pricing with one or more underlying assets based on these models. Analysis and implementation of models goes beyond the standard Black and Scholes framework and includes Markov switching models, Levy models and other models with jumps (e.g. the telegraph process); Topics other than option pricing include: volatility and covariation estimation, change point analysis, asymptotic expansion and classification of financial time series from a statistical viewpoint. The book features problems with solutions and examples. All the examples and R code are available as an additional R package, therefore all the examples can be reproduced.

Provides an introduction to the various statistical techniques involved in medical research and drug development with a focus on estimating the success probability of an experiment Success Probability Estimation with Applications to Clinical Trials details the use of success probability estimation in both the planning and analyzing of clinical trials and in widely used statistical tests. Devoted to both statisticians and non-statisticians who are involved in clinical trials, Part I of the book presents new concepts related to success probability estimation and their usefulness in clinical trials, and each section begins with a non-technical explanation of the presented concepts. Part II delves deeper into the techniques for success probability estimation and features applications to both reproducibility probability estimation and conservative sample size estimation. Success Probability Estimation with Applications to Clinical Trials: • Addresses the theoretical and practical aspects of the topic and introduces new and promising techniques in the statistical and pharmaceutical industries Features practical solutions for problems that are often encountered in clinical trials Includes success probability estimation for widely used statistical tests, such as parametric and nonparametric models Focuses on experimental planning, specifically the sample size of clinical trials using phase II results and data for planning phase III trials Introduces statistical concepts related to success probability estimation and their usefulness in clinical trials Success Probability Estimation with Applications to Clinical Trials is an ideal reference for statisticians and biostatisticians in the pharmaceutical industry as well as researchers and practitioners in medical centers who are actively involved in health policy, clinical research, and the design and evaluation of clinical trials.

Praise for the First Edition «This pioneering work, in which Rao provides a comprehensive and up-to-date treatment of small area estimation, will become a classic…I believe that it has the potential to turn small area estimation…into a larger area of importance to both researchers and practitioners.» —Journal of the American Statistical Association Written by two experts in the field, Small Area Estimation, Second Edition provides a comprehensive and up-to-date account of the methods and theory of small area estimation (SAE), particularly indirect estimation based on explicit small area linking models. The model-based approach to small area estimation offers several advantages including increased precision, the derivation of «optimal» estimates and associated measures of variability under an assumed model, and the validation of models from the sample data. Emphasizing real data throughout, the Second Edition maintains a self-contained account of crucial theoretical and methodological developments in the field of SAE. The new edition provides extensive accounts of new and updated research, which often involves complex theory to handle model misspecifications and other complexities. Including information on survey design issues and traditional methods employing indirect estimates based on implicit linking models, Small Area Estimation, Second Edition also features: Additional sections describing the use of R code data sets for readers to use when replicating applications Numerous examples of SAE applications throughout each chapter, including recent applications in U.S. Federal programs New topical coverage on extended design issues, synthetic estimation, further refinements and solutions to the Fay-Herriot area level model, basic unit level models, and spatial and time series models A discussion of the advantages and limitations of various SAE methods for model selection from data as well as comparisons of estimates derived from models to reliable values obtained from external sources, such as previous census or administrative data Small Area Estimation, Second Edition is an excellent reference for practicing statisticians and survey methodologists as well as practitioners interested in learning SAE methods. The Second Edition is also an ideal textbook for graduate-level courses in SAE and reliable small area statistics.

A complete guide to the role of high-density lipoproteins (HDL) in new and emerging therapies With high-density lipoproteins (HDL) playing an increasing role in cardiovascular disease prevention, there is a growing need for an in-depth look at HDL and its clinical value. This book summarizes the current state of knowledge in the field, providing for the first time a comprehensive, systematic, stylistically coherent, and up-to-date review of the composition, structure, heterogeneity, metabolism, epidemiology, genetics, and function of HDL. Divided into three main parts, High-Density Lipoproteins first examines normal HDL particles, then describes defective HDL, and finally addresses the therapeutic normalization of subnormal levels and defective biological activities of this lipoprotein class. The book highlights the functional properties of HDL, which are relevant to the pathophysiology of atherosclerosis and thrombosis, and discusses the compositional and metabolic heterogeneity of HDL particles. Readers will come away with a clear understanding of the role of HDL in biological processes, the potential value of functional HDL as a therapeutic target, and how current and emerging therapies are poised to influence the treatment of heart disease in the future.