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Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field. Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.


Chemical observations on sugar Chemical observations on sugar

Автор: Edward Rigby

Год издания: 

Полный вариант заголовка: «Chemical observations on sugar / by Edward Rigby».


Chemical Secret Chemical Secret

Автор: Tim Vicary

Год издания: 

A level 3 Oxford Bookworms Library graded readers. Written for Learners of English by Tim Vicary. The job was too good. There had to be a problem – and there was. John Duncan was an honest man, but he needed money. He had children to look after. He was ready to do anything, and his bosses knew it. They gave him the job because he couldn’t say no; he couldn’t afford to be honest. And the job was like a poison inside him. It changed him and blinded him, so that he couldn’t see the real poison – until it was too late.


Cigarette Smoke Toxicity. Linking Individual Chemicals to Human Diseases Cigarette Smoke Toxicity. Linking Individual Chemicals to Human Diseases

Автор: David Bernhard

Год издания: 

Smoking causes and contributes to a large number of human diseases, yet due to the large number of potentially hazardous compounds in cigarette smoke – almost 5,000 chemicals have been identified, establishing the link between smoking and disease has often proved difficult. This unbiased and scientifically accurate overview of current knowledge begins with an overview of the chemical constituents in cigarette smoke, their fate in the human body, and their documented toxic effects on various cells and tissues. Recent results detailing the many ways components of cigarette smoke adversely affect human health are also presented, highlighting the role of smoking in cardiovascular, respiratory, infectious and other diseases. A final chapter discusses current strategies for the treatment and prevention of smoking-induced illness. Despite the obvious importance of the topic, this is the first comprehensive reference on tobacco smoke toxicity, making for essential reading for all toxicologists and healthcare professionals dealing with smoking-related diseases.


Impedance Spectroscopy. Applications to Electrochemical and Dielectric Phenomena Impedance Spectroscopy. Applications to Electrochemical and Dielectric Phenomena

Автор: Vadim Lvovich F.

Год издания: 

This book presents a balance of theoretical considerations and practical problem solving of electrochemical impedance spectroscopy. This book incorporates the results of the last two decades of research on the theories and applications of impedance spectroscopy, including more detailed reviews of the impedance methods applications in industrial colloids, biomedical sensors and devices, and supercapacitive polymeric films. The book covers all of the topics needed to help readers quickly grasp how to apply their knowledge of impedance spectroscopy methods to their own research problems. It also helps the reader identify whether impedance spectroscopy may be an appropriate method for their particular research problem. This includes understanding how to correctly make impedance measurements, interpret the results, compare results with expected previously published results form similar chemical systems, and use correct mathematical formulas to verify the accuracy of the data. Unique features of the book include theoretical considerations for dealing with modeling, equivalent circuits, and equations in the complex domain, review of impedance instrumentation, best measurement methods for particular systems and alerts to potential sources of errors, equations and circuit diagrams for the most widely used impedance models and applications, figures depicting impedance spectra of typical materials and devices, extensive references to the scientific literature for more information on particular topics and current research, and a review of related techniques and impedance spectroscopy modifications.


Fluid Mechanics, Heat Transfer, and Mass Transfer. Chemical Engineering Practice Fluid Mechanics, Heat Transfer, and Mass Transfer. Chemical Engineering Practice

Автор: K. Raju S.

Год издания: 

This broad-based book covers the three major areas of Chemical Engineering. Most of the books in the market involve one of the individual areas, namely, Fluid Mechanics, Heat Transfer or Mass Transfer, rather than all the three. This book presents this material in a single source. This avoids the user having to refer to a number of books to obtain information. Most published books covering all the three areas in a single source emphasize theory rather than practical issues. This book is written with emphasis on practice with brief theoretical concepts in the form of questions and answers, not adopting stereo-typed question-answer approach practiced in certain books in the market, bridging the two areas of theory and practice with respect to the core areas of chemical engineering. Most parts of the book are easily understandable by those who are not experts in the field. Fluid Mechanics chapters include basics on non-Newtonian systems which, for instance find importance in polymer and food processing, flow through piping, flow measurement, pumps, mixing technology and fluidization and two phase flow. For example it covers types of pumps and valves, membranes and areas of their use, different equipment commonly used in chemical industry and their merits and drawbacks. Heat Transfer chapters cover the basics involved in conduction, convection and radiation, with emphasis on insulation, heat exchangers, evaporators, condensers, reboilers and fired heaters. Design methods, performance, operational issues and maintenance problems are highlighted. Topics such as heat pipes, heat pumps, heat tracing, steam traps, refrigeration, cooling of electronic devices, NOx control find place in the book. Mass transfer chapters cover basics such as diffusion, theories, analogies, mass transfer coefficients and mass transfer with chemical reaction, equipment such as tray and packed columns, column internals including structural packings, design, operational and installation issues, drums and separators are discussed in good detail. Absorption, distillation, extraction and leaching with applications and design methods, including emerging practices involving Divided Wall and Petluk column arrangements, multicomponent separations, supercritical solvent extraction find place in the book.