Скачать книгу - Amyloid Fibrils and Prefibrillar Aggregates
Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research. The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry.


Lipids and Cellular Membranes in Amyloid Diseases Lipids and Cellular Membranes in Amyloid Diseases

Автор: Raz Jelinek

Год издания: 

Addressing one of the biggest riddles in current molecular cell biology, this ground-breaking monograph builds the case for the crucial involvement of lipids and membranes in the formation of amyloid deposits. Tying together recent knowledge from in vitro and in vivo studes, and built on a sound biophysical and biochemical foundation, this overview brings the reader up to date with current models of the interplay between membranes and amyloid formation. Required reading for any researcher interested in amyloid formation and amyloid toxicity, and possible avenues for the prevention or treatment of neurodegenerative disorders. From the contents: * Interactions of Alpha-Synuclein with Lipids * Interaction of hIAPP and its Precursors with Membranes * Amyloid Polymorphisms: Structural Basis and Significance in Biology and Molecular Medicine * The Role of Lipid Rafts in Alzheimer's Disease * Alzheimer's Disease as a Membrane-Associated Enzymopathy of Beta-Amyloid Precursor Protein (APP) Secretases * Impaired Regulation of Glutamate Receptor Channels and Signaling Molecules by Beta-Amyloid in Alzheimer's Disease * Membrane Changes in BSE and Scrapie * Experimental Approaches and Technical Challenges for Studying Amyloid-Membrane Interactions and more


Analysis of Aggregates and Particles in Protein Pharmaceuticals Analysis of Aggregates and Particles in Protein Pharmaceuticals

Автор: Jiskoot Wim

Год издания: 

This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.


Mastering Data Warehouse Aggregates Mastering Data Warehouse Aggregates

Автор: Группа авторов

Год издания: 

This is the first book to provide in-depth coverage of star schema aggregates used in dimensional modeling-from selection and design, to loading and usage, to specific tasks and deliverables for implementation projects Covers the principles of aggregate schema design and the pros and cons of various types of commercial solutions for navigating and building aggregates Discusses how to include aggregates in data warehouse development projects that focus on incremental development, iterative builds, and early data loads


The Nature and Origin of Amyloid Fibrils The Nature and Origin of Amyloid Fibrils

Автор: Gregory Bock R.

Год издания: 

Amyloid fibrils are associated with a range of pathological disorders including Alzheimer's Disease, Down's syndrome, diabetes, cardiomyopathies, and transmissible spongiform encephalopathies. This volume is a comprehensive account of recent developments in the understanding of the process of amyloid fibrils. Contains up-to-date data on all of the clinical problems which, despite their pathological significance, are still largely unsolved.