Скачать книгу - Predictive ADMET. Integrated Approaches in Drug Discovery and Development



This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward. The book introduces the current clinical practice for drug discovery and development along with the impact on early risk assessment; consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data; and demonstrates successful cases and lessons learned from real drug discovery and development. In short, it is a book aimed to provide a practical road map for drug discovery and development scientists to generate efficacious and safe drugs for unmet medical needs.


Web Application
Development with PHP 4.0 Web Application Development with PHP 4.0

Автор: Tobias Ratschiller, Till Gerken

Год издания: 

While the success of Open Source software like Linux or Apache has been documented extensively throughout all mainstream media, the rise of PHP has gone largely unnoticed. Still, the Web scripting language PHP is the most popular module for the Apache Web server, according to an E-Soft survey (www.e-softinc.com/survey/). Netcraft studies have found that PHP is in use on over 6% of all Web domains in the world (see www.netcraft.com/survey).That’s an incredible market penetration for a rather specialized product.This popularity continues to rise exponentially. Increasingly, this is being reflected in traditional media: As of May, 2000, more than 20 books about PHP have been published in different languages, with more in the pipeline. Commercial players are beginning to join the bandwagon: PHP is included with Web servers, for example C2’s Stronghold, and Linux distributions. A new company, Zend Technologies, has been formed to provide commercial add-ons and support for PHP.A long list of large-scale Web sites employ PHP, as well as hundreds of thousands of small to medium Web sites.


Secure PHP Development: Building 50 Practical Applications Secure PHP Development: Building 50 Practical Applications

Автор: Mohammed J. Kabir

Год издания: 

The personal home page (PHP) server-side scripting language is particular well adapted to connecting HTML-based web pages to a backend database for dynamic content. This book explains the entire nuts-and-bolts process of the PHP application life cycle: requirements, design, development, maintenance and tuning. It shows how PHP can be used to design and develop highly manageable and secure applications to solve practical problems.


Английский язык для профессионального развития. Ресторанный и кейтеринговый бизнес / English for Professional Development. Restaurant and Catering Business Английский язык для профессионального развития. Ресторанный и кейтеринговый бизнес / English for Professional Development. Restaurant and Catering Business

Автор: О. Н. Федорова

Год издания: 



Proceedings of the Association for promoting the discovery of the interior parts of Africa Proceedings of the Association for promoting the discovery of the interior parts of Africa

Автор: Группа авторов

Год издания: 



The history of the discovery and conquest of the Canary Islands The history of the discovery and conquest of the Canary Islands

Автор: George Glas

Год издания: 

Полный вариант заголовка: «The history of the discovery and conquest of the Canary Islands : translated from a Spanish manuscript, lately found in the island of Palma : with an enquiry into the origin of the ancient inhabitants : to which is added, a dsescription of the Canary Islands, including the modern history of the inhabitants, and an account of their manners, customs, trade, & c. / by George Glas».