Скачать книгу - Absorption and Drug Development. Solubility, Permeability, and Charge State



Explains how to perform and analyze the results of the latest physicochemical methods With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates. This Second Edition has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including: Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier Expanded information and methods to support pKa determination New examples explaining the treatment of practically insoluble test compounds Additional case studies demonstrating the use of the latest physicochemical techniques New, revised, and expanded database tables throughout the book Well over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book. This Second Edition is recommended as a reference for researchers in pharmaceutical R&D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics.


Real Estate: изучаем английский язык. Учебное пособие Real Estate: изучаем английский язык. Учебное пособие

Автор: Е. А. Игнатьева

Год издания: 



The Statement of Randolph Carter The Statement of Randolph Carter

Автор: Говард Филлипс Лавкрафт

Год издания: 

"The Statement of Randolph Carter" is a short story by H. P. Lovecraft which tells of a traumatic event in the life of Randolph Carter, a student of the occult loosely representing Lovecraft himself.


Английский язык для профессионального развития. Ресторанный и кейтеринговый бизнес / English for Professional Development. Restaurant and Catering Business Английский язык для профессионального развития. Ресторанный и кейтеринговый бизнес / English for Professional Development. Restaurant and Catering Business

Автор: О. Н. Федорова

Год издания: 



Совершенствуйте навыки работы с текстом: готовимся к государственному экзамену / Brush up your text skills: Getting prepared for the state exam Совершенствуйте навыки работы с текстом: готовимся к государственному экзамену / Brush up your text skills: Getting prepared for the state exam

Автор: С. Ю. Степанова

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A Charge of Valor A Charge of Valor

Автор: Морган Райс

Год издания: 

In A CHARGE OF VALOR (Book #6 in the Sorcerer's Ring), Thor continues on his quest, deeper into the Empire, to retrieve the stolen Destiny Sword and save the Ring. As he and his friends meet unexpected tragedy and lose a member of their close-knit group, Thor and his remaining friends become closer than they ever were, learning that they must face and overcome adversity together. Their journey takes them to new and exotic terrains, including the desolate Salt Fields, the Great Tunnel, and the Mountains of Fire, as they face a host of unexpected monsters at every turn. Thor’s skills deepen as he undergoes his most advanced training yet, and he will need to draw on powers greater than he has ever used if he is to survive. They finally discover where the Sword has been taken, and they learn that, to retrieve it, they will have to venture to the most dreaded place in the Empire: the Land of the Dragons. Back in the Ring, Gwendolyn recovers slowly and grapples with deep depression after her attack. Kendrick and the others vow to fight for her honor, despite the impossible odds. There follows one of the great battles in the history of the Ring, as they struggle to free Silesia and conquer Andronicus. Meanwhile, Godfrey finds himself in disguise behind enemy lines and begins to come into his own, learning what it means to become a warrior, in his own, unique way. Gareth manages to stay alive, using all his cunning to avert capture by Andronicus, while Erec fights for his life to save Savaria from the oncoming invasion by Andronicus – and to save his love, Alistair. Argon pays a precious price for doing the forbidden: meddling in human affairs. And Gwendolyn must decide if she will give up on life, or take up the secluded life of a nun in the ancient Tower of Refuge. But not before, in a shocking twist, Thor finally learns who his real father is. Will Thor and the others survive the quest? Will they retrieve the Destiny Sword? Will the Ring survive Andronicus’ invasion? What will become of Gwendolyn, Kendrick and Erec? And who is Thor’s real father? With its sophisticated world-building and characterization, A CHARGE OF VALOR is an epic tale of friends and lovers, of rivals and suitors, of knights and dragons, of intrigues and political machinations, of coming of age, of broken hearts, of deception, ambition and betrayal. It is a tale of honor and courage, of fate and destiny, of sorcery. It is a fantasy that brings us into a world we will never forget, and which will appeal to all ages and genders. It is 70,000 words.