Скачать книгу - Replacing Animal Models. A Practical Guide to Creating and Using Culture-based Biomimetic Alternatives



Over the last decade, in vitro models have become more sophisticated and are at a stage where they can provide an effective alternative to in vivo experiments. Replacing Animal Models provides scientists and technicians with a practical, integrated guide to developing culture-based alternatives to in vivo experiments. The book is neither political nor polemical: it is technical, illustrating by example how alternatives can be developed and used and providing useful advice on developing others. After looking at the reasons for and potential benefits of alternatives to animal experiments, the book covers a range of methods and examples emphasising the design considerations that went into each system. The chapters also include 'case studies' that illustrate the ways in which culture models can be used to answer a range of important biological questions of direct relevance to human development, physiology, disease and healing. The thesis of this book is not that all animal experimentation can be replaced, now or in the near future, by equally effective or superior alternatives. Rather, the premise is that there is substantial opportunity, here and now, to do some common types of experiment better in vitro than in vivo, and that doing so will result in both scientific and ethical gains.


Testing SAP R/3
A Manager’s Step-by-Step Guide Testing SAP R/3 A Manager’s Step-by-Step Guide

Автор: JOSE FAJARDO, ELFRIEDE DUSTIN

Год издания: 

Planning, preparing, scheduling, and executing SAP test cycles is a time-consuming and resource-intensive endeavor that requires participation from several project members. SAP projects are prone to have informal, ad-hoc test approaches that decrease the stability of the production environment and tend to increase the cost of ownership for the SAP system. Many SAP project and test managers cannot provide answers for questions such as how many requirements have testing coverage, the exit criteria for a test phase, the audit trails for test results, the dependencies and correct sequence for executing test cases, or the cost figures for a previously executed test cycle. Fortunately, through established testing techniques predicated on guidelines and methodologies (i.e., ASAP SAP Roadmap methodology, IBM’s Ascendant methodology, and Deloitte’s ThreadManager methodology), enforcement of standards, application of objective testing criteria, test case automation, implementation of a requirements traceability matrix (RTM), and independent testing and formation of centralized test teams, many of the testing risks that plague existing or initial SAP programs can be significantly reduced. This book is written for SAP managers, SAP consultants, SAP testers, and team leaders who are tasked with supporting, managing, implementing, and monitoring testing activities related to test planning, test design, test automation, test tool management, execution of test cases, reporting of test results, test outsourcing, planning a budget for testing activities, enforcing testing standards, and resolving defects.


Secure PHP Development: Building 50 Practical Applications Secure PHP Development: Building 50 Practical Applications

Автор: Mohammed J. Kabir

Год издания: 

The personal home page (PHP) server-side scripting language is particular well adapted to connecting HTML-based web pages to a backend database for dynamic content. This book explains the entire nuts-and-bolts process of the PHP application life cycle: requirements, design, development, maintenance and tuning. It shows how PHP can be used to design and develop highly manageable and secure applications to solve practical problems.


Oracle Database 10g: A Beginner's Guide Oracle Database 10g: A Beginner's Guide

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Two new Oracle instruction and resource titles from Osborne/McGraw-Hill are indispensable additions to personal and professional reference collections. Oracle Database 10g: A Beginner's Guide is the collective effort of Oracle experts Ian Abramson, Michael Abbey and Michael Corey. Oracle Database 10g provides neophytes with the fundamental concepts of Oracle Database 10g administration and programming. Through self-paced tutorials, readers will learn about database essentials, the role of the administrator, and large database features. Oracle Database 10g includes an in-depth introduction to SQL, PL/SQL, Java, and XML programming.


Photoshop CS2 Raw: Using Adobe Camera Raw, Bridge, and Photoshop to Get the Most Out of Your Digital Camera Photoshop CS2 Raw: Using Adobe Camera Raw, Bridge, and Photoshop to Get the Most Out of Your Digital Camera

Автор: Aaland Mikkel

Год издания: 

The RAW file format is the uncompressed data file captured by a digital camera's electronic sensor. When your camera saves an image in RAW format, settings like white balance, sharpening, contrast and saturation are not applied to the image but are saved instead in a separate header. Because RAW files remain virtually untouched by in-camera processing, they are essentially the digital equivalent to exposed but undeveloped film. This makes RAW an increasingly popular format with amateur and professional digital photographers, because it affords greater flexibility and control during the editing process-if you know how to work with RAW files. Most digital camera manufacturers supply their own software for converting RAW data, as do some third party vendors. Increasingly, however, the RAW converter of choice is a plug-in included in the latest version of Adobe Photoshop, the most popular and widely-used digital image editing tool in the world. Adobe Photoshop CS2 is emerging as the best place to edit RAW images, and the best way to master this new format is with Photoshop CS2 RAW. An important book dedicated to working with RAW in Photoshop, this comprehensive guide features a unique design that helps readers grasp the subject through visual instruction and prompts. The entire RAW process is explored, from shooting to using the Adobe plug-in converter and new Bridge navigation software. The primary focus of Photoshop RAW is, as the title suggests, Photoshop editing technique: automating RAW workflow, correcting exposures, extending exposure range, manipulating grayscale and working with the new DNG (Digital Negative) open standard that Adobe supports. Presented by photographer Mikkel Aaland, a pioneer of digital photography and author of eight books, including O"Reilly"s Photoshop for the Web and the award-winning Shooting Digital, Photoshop CS2 RAW investigates and instructs in an accessible visual style. Required reading for professionals and dedicated photo hobbyists alike.


Horses and Other Animals In Motion. 45 Classic Photographic Sequences Horses and Other Animals In Motion. 45 Classic Photographic Sequences

Автор: Muybridge Eadweard

Год издания: 

Эта книга - сборник фотографий различных животных в движении. Фотографии сделаны со скоростью 1/2000 секунды, и полученные секвенции кадров представляют собой типичные движения лошадей и других животных на расчерченном вспомогательной сеткой фоне. Большинство секвенций включают снимки с нескольких углов зрения. Лошади показаны в ходьбе, рыси, легком галопе, галопе, тянущими повозку и т.д. Также представлены движения собак, кошек, свиней, слона, козы, птиц и др. Книга является репринтом издания, выпущенного в 1887 году. На мой взгляд, будет полезна художникам в качестве референсов при изображении животных.